High Density Lipoprotein Cholesterol (HDL-C) is seen as the 'good' cholesterol (relative to LDL-C). Its job is to bring circulating cholesterol and fatty acids back to the liver tissue and clear them from the blood; high levels are desired to protect the heart.

This page features 33 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect HDL-C
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Garlic
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
A Fish Oil
A Policosanol
A Chromium
A Cocoa Extract
A Conjugated Linoleic Acid
A Red Clover Extract
B Vitamin B3
B Berberine
B Curcumin
B Green Tea Catechins
B Inositol
B Olive leaf extract
B Psyllium
B Spirulina
B Astaxanthin
B Dehydroepiandrosterone
B Grape Seed Extract
B Hesperidin
B L-Carnitine
B Lactobacillus reuteri
B Magnesium
B Nigella sativa
B Trimethylglycine
B Vitamin E
C Ganoderma lucidum
C Krill Oil
C Ashwagandha
C Ephedrine
C Fenugreek
C Ginger
C Guggul
C Irvingia gabonensis
C Panax ginseng
C Pterostilbene
C Pueraria mirifica
C Punicic Acid
C Quercetin
C Rooibos
C Shilajit
C Anethum graveolens
C Artichoke Extract
C Benfotiamine
C Black Cohosh
C Blueberry
C Caffeine
C Citrulline
C Citrullus colocynthis
C Creatine
C Eleutherococcus senticosus
C Gamma Oryzanol
C Garcinia cambogia
C Green Coffee Extract
C Gynostemma pentaphyllum
C Hemp Protein
C Hibiscus sabdariffa
C Japanese Knotweed
C Licorice
C Melatonin
C Microlactin
C Nattokinase
C Phosphatidylcholine
C Phosphatidylserine
C Pyruvate
C Resveratrol
C Rose Hip
C Royal Jelly
C Salvia hispanica
C Sea Buckthorn
C Soy lecithin
C Stevia
C Theaflavins
C Vanadium
C Vitamin C
C Vitamin K
C Whey Protein
C Yacon
C Zinc
D Coleus forskohlii
D Ruscus aculeatus
D Coconut Oil
D Coffee
D Emblica officinalis
D Pycnogenol
D Safflower Oil
D Tauroursodeoxycholic Acid
D Tetradecyl Thioacetic Acid
D Yerba mate
D Ecklonia cava
D Eclipta alba
D Horse Chestnut
D Mangifera indica
D Perilla Oil
D Pueraria lobata
D Pyrroloquinoline quinone
D Rubus coreanus


  1. Fernandez ML Dietary cholesterol provided by eggs and plasma lipoproteins in healthy populations . Curr Opin Clin Nutr Metab Care. (2006)
  2. Djoussé L, et al Egg consumption and risk of type 2 diabetes in older adults . Am J Clin Nutr. (2010)
  3. Flynn MA, et al Serum lipids and eggs . J Am Diet Assoc. (1986)
  4. Bowman MP, et al Effect of dietary fat and cholesterol on plasma lipids and lipoprotein fractions in normolipidemic men . J Nutr. (1988)
  5. Chenoweth W, et al Influence of dietary cholesterol and fat on serum lipids in men . J Nutr. (1981)
  6. Effect of dietary eggs and ascorbic acid on plasma lipid and lipoprotein cholesterol levels in healthy young men
  7. Egg intake does not change plasma lipoprotein and coagulation profiles
  8. Johnson C, Greenland P Effects of exercise, dietary cholesterol, and dietary fat on blood lipids . Arch Intern Med. (1990)
  9. Sacks FM, et al Ingestion of egg raises plasma low density lipoproteins in free-living subjects . Lancet. (1984)
  10. Down-regulation of the low-density lipoprotein receptor by dietary cholesterol
  11. A double-blind, randomized, controlled trial of the effects of two eggs per day in moderately hypercholesterolemic and combined hyperlipidemic subjects taught the NCEP step I diet
  12. Romano G, et al Effects of dietary cholesterol on plasma lipoproteins and their subclasses in IDDM patients . Diabetologia. (1998)
  13. Mayurasakorn K, et al High-density lipoprotein cholesterol changes after continuous egg consumption in healthy adults . J Med Assoc Thai. (2008)
  14. Vishwanathan R, et al Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in older adults with low macular pigment taking cholesterol-lowering statins . Am J Clin Nutr. (2009)
  15. Katz DL, et al Egg consumption and endothelial function: a randomized controlled crossover trial . Int J Cardiol. (2005)
  16. Njike V, et al Daily egg consumption in hyperlipidemic adults--effects on endothelial function and cardiovascular risk . Nutr J. (2010)
  17. Jones PJ Dietary cholesterol and the risk of cardiovascular disease in patients: a review of the Harvard Egg Study and other data . Int J Clin Pract Suppl. (2009)
  18. Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis
  19. Fernandez ML Effects of eggs on plasma lipoproteins in healthy populations . Food Funct. (2010)
  20. McNamara DJ The impact of egg limitations on coronary heart disease risk: do the numbers add up . J Am Coll Nutr. (2000)
  21. Fernandez ML, Calle M Revisiting dietary cholesterol recommendations: does the evidence support a limit of 300 mg/d . Curr Atheroscler Rep. (2010)
  22. Eggs, serum cholesterol, and coronary heart disease
  23. Hu FB, et al A prospective study of egg consumption and risk of cardiovascular disease in men and women . JAMA. (1999)
  24. Spence JD, Jenkins DJ, Davignon J Dietary cholesterol and egg yolks: not for patients at risk of vascular disease . Can J Cardiol. (2010)
  25. Herron KL, et al High intake of cholesterol results in less atherogenic low-density lipoprotein particles in men and women independent of response classification . Metabolism. (2004)
  26. Pearce KL, Clifton PM, Noakes M Egg consumption as part of an energy-restricted high-protein diet improves blood lipid and blood glucose profiles in individuals with type 2 diabetes . Br J Nutr. (2011)
  27. Goodrow EF, et al Consumption of one egg per day increases serum lutein and zeaxanthin concentrations in older adults without altering serum lipid and lipoprotein cholesterol concentrations . J Nutr. (2006)
  28. Effect of a High Saturated Fat and No-Starch Diet on Serum Lipid Subfractions in Patients With Documented Atherosclerotic Cardiovascular Disease
  29. Mutungi G, et al Dietary cholesterol from eggs increases plasma HDL cholesterol in overweight men consuming a carbohydrate-restricted diet . J Nutr. (2008)
  30. Mutungi G, et al Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men following a carbohydrate-restricted diet . J Nutr Biochem. (2010)
  31. Fern√°ndez-Robredo P, et al Egg yolk improves lipid profile, lipid peroxidation and retinal abnormalities in a murine model of genetic hypercholesterolemia . J Nutr Biochem. (2008)
  32. Evans SF1, et al Mango supplementation improves blood glucose in obese individuals . Nutr Metab Insights. (2014)
  33. Pardo-Andreu GL1, et al Mangifera indica L. (Vimang) protection against serum oxidative stress in elderly humans . Arch Med Res. (2006)

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