Glycemic control

Scientific Information on Glycemic control

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Glycemic control

Level of Evidence	Supplement	Change	Magnitude of Effect Size	Scientific Consensus	Comments
B	Creatine		Minor	100% See all 3 studies	Appears to be somewhat effective in diabetics for improving glycemic control.
C	Fenugreek		Minor	100% See study	May improve glycemic control secondary to reduction in blood glucose, although this may be more indicative of fenugreek fibers than the saponin content
C	Chlorogenic Acid		Minor	0% See study	Slight increase in glycemic control possibly secondary to reducing carbohydrate absorption
C	Vitamin C			100% See study	No significant influence on glycemic control in diabetics with Vitamin C supplementation
D	Alpha-Lipoic Acid			100% See study	No significant practical benefit on glycemic control noted

References

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25. Ristow M, et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A. (2009)
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27. Chuin A, et al. Effect of antioxidants combined to resistance training on BMD in elderly women: a pilot study. Osteoporos Int. (2009)
28. Block G, et al. Vitamin C treatment reduces elevated C-reactive protein. Free Radic Biol Med. (2009)
29. Retana-Ugalde R, et al. High dosage of ascorbic acid and alpha-tocopherol is not useful for diminishing oxidative stress and DNA damage in healthy elderly adults. Ann Nutr Metab. (2008)
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36. Bryant RJ, et al. Effects of vitamin E and C supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists. J Strength Cond Res. (2003)
37. Fuller CJ, May MA, Martin KJ. The effect of vitamin E and vitamin C supplementation on LDL oxidizability and neutrophil respiratory burst in young smokers. J Am Coll Nutr. (2000)
38. Johnston CS, Dancho CL, Strong GM. Orange juice ingestion and supplemental vitamin C are equally effective at reducing plasma lipid peroxidation in healthy adult women. J Am Coll Nutr. (2003)
39. Kim MK, et al. Long-term vitamin C supplementation has no markedly favourable effect on serum lipids in middle-aged Japanese subjects. Br J Nutr. (2004)
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41. Thompson D, et al. Prolonged vitamin C supplementation and recovery from eccentric exercise. Eur J Appl Physiol. (2004)
42. Kinlay S, et al. Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function. J Am Coll Cardiol. (2004)
43. Van Hoydonck PG, et al. Does vitamin C supplementation influence the levels of circulating oxidized LDL, sICAM-1, sVCAM-1 and vWF-antigen in healthy male smokers. Eur J Clin Nutr. (2004)
44. Mastaloudis A, et al. Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radic Biol Med. (2004)
45. Huck CJ, et al. Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet. Nutrition. (2012)
46. Davison G, Gleeson M. The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man. Eur J Appl Physiol. (2006)

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