Fatigue Resistance

Fatigue Resistance tends to refer to the resiliance of the body towards developing fatigue (a sort of preeminative anti-fatigue effect), and supplements that enhance fatigue resistance are thought to be anti-stress and adaptogenic.

This page features 12 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Fatigue Resistance
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
B Creatine
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
C Eleutherococcus senticosus
C Astaxanthin


  1. Belcaro G, et al MF AfragilĀ® in the treatment of 34 menopause symptoms: a pilot study . Panminerva Med. (2010)
  2. Tominaga K, et al Cosmetic benefits of astaxanthin on humans subjects . Acta Biochim Pol. (2012)
  3. Djordjevic B, et al Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players . J Sports Med Phys Fitness. (2012)
  4. Saito M, et al Astaxanthin increases choroidal blood flow velocity . Graefes Arch Clin Exp Ophthalmol. (2012)
  5. Miyawaki H, et al Effects of astaxanthin on human blood rheology . J Clin Biochem Nutr. (2008)
  6. Comhaire FH, et al Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial . Asian J Androl. (2005)
  7. Earnest CP, et al Effect of astaxanthin on cycling time trial performance . Int J Sports Med. (2011)
  8. Miyazawa T, et al Erythrocytes carotenoids after astaxanthin supplementation in middle-aged and senior Japanese subjects . J Oleo Sci. (2011)
  9. Nakagawa K, et al Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes . Br J Nutr. (2011)
  10. Choi HD, Youn YK, Shin WG Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects . Plant Foods Hum Nutr. (2011)
  11. Choi HD, et al Effects of astaxanthin on oxidative stress in overweight and obese adults . Phytother Res. (2011)
  12. Yoshida H, et al Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia . Atherosclerosis. (2010)

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