Exercise-induced Oxidation

Scientific Information on Exercise-induced Oxidation

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Exercise-induced Oxidation

Level of Evidence	Supplement	Change	Magnitude of Effect Size	Scientific Consensus	Comments
B	L-Carnitine		Minor	80% See all 5 studies	A decrease in the exercise-induced increase in MDA levels is seen with carnitine supplementation, possibly secondary to reducing damage to muscle tissue. The degree of... show MDA reduction is not overly remarkable
B	Coenzyme Q10		Minor	50% See all 4 studies	Mixed effects on exercise-induced oxidation, but there appears to be some potential for CoQ10 supplementation to reduce oxidation.
C	Green Tea Catechins		Minor	100% See study	A decrease in the oxidation that occurs during exercise may occur following acute ingestion of green tea catechins
C	Melatonin		Minor	100% See 2 studies	Related to the antioxidative effects, a reduction in exercise-induced oxidation has been noted
C	Vitamin C			0% See 2 studies	Highly mixed interactions with the exercise:oxidation axis with Vitamin C, with both increases and decreases being noted. Unlikely to have a reliable role
C	Methylsulfonylmethane		Notable	100% See study	A decrease in exercise induced oxidation is noted with MSM supplementation and thought to be the underlying reason for reductions in muscle damage and soreness. The degree... show of reduction seems to be notable, as the increase in MDA and protein carbonylation were fully abolished
C	Fish Oil		Minor	100% See study	Exercise induced oxidation has been noted to be increased in elite athletes with fish oil supplementation
C	Phosphatidylserine			100% See study	No significant influence on oxidation biomarkers that are increased during exercise

References

1. Hirayama S, et al. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. J Hum Nutr Diet. (2013)
2. Parker AG, et al. The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise. J Int Soc Sports Nutr. (2011)
3. Schreiber S, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci. (2000)
4. Kato-Kataoka A, et al. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. (2010)
5. Manor I, et al. The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: a double-blind placebo-controlled trial, followed by an open-label extension. Eur Psychiatry. (2012)
6. Vakhapova V, et al. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. Dement Geriatr Cogn Disord. (2010)
7. Baumeister J, et al. Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutr Neurosci. (2008)
8. Jorissen BL, et al. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr Neurosci. (2001)
9. Kingsley MI, et al. Effects of phosphatidylserine on exercise capacity during cycling in active males. Med Sci Sports Exerc. (2006)
10. Kingsley MI, et al. Phosphatidylserine supplementation and recovery following downhill running. Med Sci Sports Exerc. (2006)
11. Engel RR, et al. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol. (1992)
12. Crook T, et al. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull. (1992)
13. Monteleone P, et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol. (1992)

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