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Exercise Capacity in COPD

   

Table of Contents

    Summary (All Essential Benefits/Effects/Facts & Information)

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    Scientific Information on Exercise Capacity in COPD

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    Human Effect Matrix

    The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Exercise Capacity in COPD
    GradeLevel of Evidence
    ARobust research conducted with repeated double blind clinical trials
    BMultiple studies where at least two are double-blind and placebo controlled
    CSingle double blind study or multiple cohort studies
    DUncontrolled or observational studies only
    Level of Evidence
    		SupplementChange
    		Magnitude of Effect Size
    		Scientific ConsensusComments
    BCreatine

    The cardiovascular system does not appear to have greater exercise capacity following supplementation with creatine in persons with COPD

    CGlutamine

    No significant interaction with exercise capacity in persons with cardiovascular ailment

    Scientific Support & Reference Citations

    References

    1. Rotovnik Kozjek N, et al. Oral glutamine supplementation during preoperative radiochemotherapy in patients with rectal cancer: a randomised double blinded, placebo controlled pilot study. Clin Nutr. (2011)
    2. Marwood S, et al. No effect of glutamine ingestion on indices of oxidative metabolism in stable COPD. Respir Physiol Neurobiol. (2011)
    3. Awad S, et al. A randomized cross-over study of the metabolic and hormonal responses following two preoperative conditioning drinks. Nutrition. (2011)
    4. Yalçin SS, et al. Effect of glutamine supplementation on lymphocyte subsets in children with acute diarrhea. Turk J Pediatr. (2010)
    5. Galera SC, et al. The safety of oral use of L-glutamine in middle-aged and elderly individuals. Nutrition. (2010)
    6. Marton S, et al. Effect of glutamine in patients with esophagus resection. Dis Esophagus. (2010)
    7. Eroglu A. The effect of intravenous alanyl-glutamine supplementation on plasma glutathione levels in intensive care unit trauma patients receiving enteral nutrition: the results of a randomized controlled trial. Anesth Analg. (2009)
    8. Mok E, et al. Lack of functional benefit with glutamine versus placebo in Duchenne muscular dystrophy: a randomized crossover trial. PLoS One. (2009)
    9. Carvalho-Peixoto J, Alves RC, Cameron LC. Glutamine and carbohydrate supplements reduce ammonemia increase during endurance field exercise. Appl Physiol Nutr Metab. (2007)
    10. Bassini-Cameron A, et al. Glutamine protects against increases in blood ammonia in football players in an exercise intensity-dependent way. Br J Sports Med. (2008)
    11. Benjamin J, et al. Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. Dig Dis Sci. (2012)
    12. Den Hond E, et al. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. JPEN J Parenter Enteral Nutr. (1999)
    13. Akobeng AK, et al. Glutamine supplementation and intestinal permeability in Crohn's disease. JPEN J Parenter Enteral Nutr. (2000)

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