Erections refers to the ability to achieve and maintain and erection as well as its rigidity. Many supplements catering towards erectile dysfunction are said to possess these pro-erectile properties.

This page features 23 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Erections
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
B Panax ginseng
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
B Yohimbine
C Coenzyme Q10
C Eurycoma Longifolia Jack
C Maca
C Tribulus terrestris
C Ashwagandha
C Butea superba
C Dehydroepiandrosterone
C Saffron
D Citrulline
D L-Carnitine
D Pycnogenol


  1. Nahid K, et al The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial . J Midwifery Womens Health. (2009)
  2. Hausenblas HA, et al Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials . J Integr Med. (2013)
  3. Kianbakht S, Ghazavi A Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial . Phytother Res. (2011)
  4. Akhondzadeh S, et al A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease . Psychopharmacology (Berl). (2010)
  5. Akhondzadeh S, et al Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial . J Clin Pharm Ther. (2010)
  6. Akhondzadeh Basti A, et al Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial . Prog Neuropsychopharmacol Biol Psychiatry. (2007)
  7. Falsini B, et al Influence of saffron supplementation on retinal flicker sensitivity in early age-related macular degeneration . Invest Ophthalmol Vis Sci. (2010)
  8. Kashani L, et al Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study . Hum Psychopharmacol. (2013)
  9. Modabbernia A, et al Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial . Psychopharmacology (Berl). (2012)
  10. Safarinejad MR, Shafiei N, Safarinejad S An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment . Int J Impot Res. (2010)
  11. Shamsa A, et al Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study . Phytomedicine. (2009)
  12. Gout B, Bourges C, Paineau-Dubreuil S Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women . Nutr Res. (2010)
  13. Verma SK, Bordia A Antioxidant property of Saffron in man . Indian J Med Sci. (1998)
  14. Agha-Hosseini M, et al Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial . BJOG. (2008)
  15. Safarinejad MR, Shafiei N, Safarinejad S A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia . Phytother Res. (2011)
  16. Heidary M, et al Effect of saffron on semen parameters of infertile men . Urol J. (2008)
  17. Golmohammadzadeh S1, Jaafari MR2, Hosseinzadeh H3 Does saffron have antisolar and moisturizing effects . Iran J Pharm Res. (2010)
  18. Fukui H, Toyoshima K, Komaki R Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus) . Phytomedicine. (2011)
  19. Akhondzadeh S, et al Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial . Phytother Res. (2005)
  20. Akhondzadeh S, et al Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial ISRCTN45683816 . BMC Complement Altern Med. (2004)
  21. Noorbala AA, et al Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial . J Ethnopharmacol. (2005)
  22. Moshiri E, et al Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial . Phytomedicine. (2006)
  23. Marangoni D, et al Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report . J Transl Med. (2013)

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