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Scientific Information on DNA damage
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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect DNA damage
|Grade||Level of Evidence|
|A||Robust research conducted with repeated double blind clinical trials|
|B||Multiple studies where at least two are double-blind and placebo controlled|
|C||Single double blind study or multiple cohort studies|
|D||Uncontrolled or observational studies only|
|Level of Evidence ||Supplement||Change||Magnitude of Effect Size ||Scientific Consensus||Comments|
No significant influences on DNA damage
|C||Conjugated Linoleic Acid|
Insufficient evidence to suggest alterations in the rate of DNA damage with CLA ingestion.
A decrease in DNA damage biomarker has been noted, thought to be secondary to antioxidative effects
Has once failed to modify the DNA damage observed in male smokers
Appears to reduce exercise-induced DNA damage; practical relevance unknown but potentially promising for cancer prevention.
|C||Olive leaf extract|
The one study to measure DNA damage (via 8-oxo-dGF as a biomarker) noted up to 50% reductions in mitochondrial and urine measurements; a fairly significant reduction.
DNA damage biomarkers have been reduced following watercress consumption
A decrease in DNA damage has been noted to be secondary to reducing arsenic toxicity
DNA damage in lymphocytes of volunteers given the polysaccharides appear unchanged
Can decrease the rates of DNA damage noted in lymphocytes, which may be related to the anticancer effects of panax ginseng
Does not appear to influence DNA damage
No significant influence of citrulline on DNA damage
A reduction in DNA damage has been noted with lemon balm tea in persons exposed to high levels of radiation