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DNA damage

   

Table of Contents

    Summary (All Essential Benefits/Effects/Facts & Information)

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    Scientific Information on DNA damage

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    Human Effect Matrix

    The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect DNA damage
    GradeLevel of Evidence
    ARobust research conducted with repeated double blind clinical trials
    BMultiple studies where at least two are double-blind and placebo controlled
    CSingle double blind study or multiple cohort studies
    DUncontrolled or observational studies only
    Level of Evidence
    		SupplementChange
    		Magnitude of Effect Size
    		Scientific ConsensusComments
    CVitamin C

    No significant influences on DNA damage

    CConjugated Linoleic Acid

    Insufficient evidence to suggest alterations in the rate of DNA damage with CLA ingestion.

    CEleutherococcus senticosus

    Minor

    A decrease in DNA damage biomarker has been noted, thought to be secondary to antioxidative effects

    CChlorella

    Has once failed to modify the DNA damage observed in male smokers

    CCreatine

    Minor

    Appears to reduce exercise-induced DNA damage; practical relevance unknown but potentially promising for cancer prevention.

    COlive leaf extract

    Notable

    The one study to measure DNA damage (via 8-oxo-dGF as a biomarker) noted up to 50% reductions in mitochondrial and urine measurements; a fairly significant reduction.

    CWatercress

    Minor

    DNA damage biomarkers have been reduced following watercress consumption

    CCurcumin

    Minor

    A decrease in DNA damage has been noted to be secondary to reducing arsenic toxicity

    CGanoderma Lucidum

    DNA damage in lymphocytes of volunteers given the polysaccharides appear unchanged

    CPanax Ginseng

    Minor

    Can decrease the rates of DNA damage noted in lymphocytes, which may be related to the anticancer effects of panax ginseng

    CFish Oil

    Does not appear to influence DNA damage

    CCitrulline

    No significant influence of citrulline on DNA damage

    DMelissa officinalis

    Minor

    A reduction in DNA damage has been noted with lemon balm tea in persons exposed to high levels of radiation

    Scientific Support & Reference Citations

    References

    1. Sureda A, et al. L-citrulline-malate influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol. (2010)
    2. Thibault R, et al. Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over study. Clin Nutr. (2011)
    3. Moinard C, et al. Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study. Br J Nutr. (2008)
    4. Bendahan D, et al. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med. (2002)
    5. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. (2010)
    6. Cormio L, et al. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. (2011)
    7. Orozco-Gutiérrez JJ, et al. Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction. Cardiol J. (2010)
    8. Hickner RC, et al. L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Med Sci Sports Exerc. (2006)
    9. Sureda A, et al. Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise. Free Radic Res. (2009)
    10. Ochiai M, et al. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men. Int J Cardiol. (2012)
    11. Figueroa A, et al. Oral L-citrulline supplementation attenuates blood pressure response to cold pressor test in young men. Am J Hypertens. (2010)

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