C-Reactive Protein

C-Reactive Protein is an inflammatory biomarker for cardiovascular disease and artherosclerosis (arterial plaque). Its reduction is thought to be protective and reduces the risk of cardiovascular incidents.

This page features 19 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect C-Reactive Protein
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Fish Oil
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
B Curcumin
B Hesperidin
B Zinc
B Cocoa Extract
B Conjugated Linoleic Acid
B L-Carnitine
B Vitamin E
C Ashwagandha
C Krill Oil
C Fucoxanthin
C Ginkgo biloba
C Grape Seed Extract
C Irvingia gabonensis
C Magnesium
C Rhodiola Rosea
C Salvia hispanica
C Stinging Nettle
C Vitamin C
C Alanylglutamine
C Alpha-Lipoic Acid
C Black Cohosh
C Blueberry
C Chromium
C Citrulline
C Coenzyme Q10
C Colostrum
C Creatine
C Feverfew
C Ganoderma lucidum
C Garlic
C Glutamine
C Lactobacillus casei
C Lactobacillus reuteri
C Melatonin
C Nigella sativa
C Panax ginseng
C Pycnogenol
C Resveratrol
C Rooibos
C Rose Hip
C S-Adenosyl Methionine
C Sea Buckthorn
C Type II Collagen
C Vitamin B2
C Vitamin B3
C Vitamin K
C Whey Protein
D Ecklonia cava
D Pyrroloquinoline quinone
D Iodine
D Safflower Oil
D Boron
D Inositol
D Perilla Oil
D Royal Jelly
D Rubus coreanus
D Tetradecyl Thioacetic Acid


  1. Al-Jenoobi FI, et al Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects . Drug Metab Lett. (2010)
  2. Dirjomuljono M, et al Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract . Int J Clin Pharmacol Ther. (2008)
  3. Hamed A, Alobaidi A Effect of Nigella Sativa and Allium Sativum Coadminstered with Simvastatin in Dyslipidemia Patients: A Prospective, Randomized, Double-blind Trial . Antiinflamm Antiallergy Agents Med Chem. (2013)
  4. Salem EM, et al Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia . Saudi J Gastroenterol. (2010)
  5. Sabzghabaee AM, et al Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial . Med Arh. (2012)
  6. Gheita TA, Kenawy SA Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study . Phytother Res. (2012)
  7. Bamosa AO, et al Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus . Indian J Physiol Pharmacol. (2010)
  8. Nikakhlagh S, et al Herbal treatment of allergic rhinitis: the use of Nigella sativa . Am J Otolaryngol. (2011)
  9. Kalus U, et al Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases . Phytother Res. (2003)
  10. Najmi A, et al Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome . Int J Diabetes Dev Ctries. (2008)
  11. I┼čik H, et al Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients . Med Princ Pract. (2010)
  12. Akhondian J, et al The effect of thymoquinone on intractable pediatric seizures (pilot study) . Epilepsy Res. (2011)
  13. Qidwai W, et al Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial . J Altern Complement Med. (2009)
  14. Dehkordi FR, Kamkhah AF Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension . Fundam Clin Pharmacol. (2008)
  15. Boskabady MH, et al The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients . Fundam Clin Pharmacol. (2007)
  16. Boskabady MH, Farhadi J The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial . J Altern Complement Med. (2008)
  17. Datau EA, et al Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male . Acta Med Indones. (2010)
  18. Barakat EM, El Wakeel LM, Hagag RS Effects of Nigella sativa on outcome of hepatitis C in Egypt . World J Gastroenterol. (2013)
  19. Bin Sayeed MS, et al The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers . J Ethnopharmacol. (2013)

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