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Alertness

   

Table of Contents

    Summary (All Essential Benefits/Effects/Facts & Information)

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    Scientific Information on Alertness

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    Human Effect Matrix

    The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Alertness
    GradeLevel of Evidence
    ARobust research conducted with repeated double blind clinical trials
    BMultiple studies where at least two are double-blind and placebo controlled
    CSingle double blind study or multiple cohort studies
    DUncontrolled or observational studies only
    Level of Evidence
    		SupplementChange
    		Magnitude of Effect Size
    		Scientific ConsensusComments
    CMelissa officinalis

    Notable

    A decrease in alertness appears to occur alongside lemon balm ingestion (with or without sedation)

    CMelatonin

    Minor

    A decrease in alertness has been noted with melatonin supplementation

    DCreatine

    Minor

    Increases in alertness tend to be during sleep deprivation or stress, rather than outright increases in alertness. Not overly potent

    Scientific Support & Reference Citations

    References

    1. Schernhammer ES, et al. A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers. Cancer Causes Control. (2012)
    2. Schernhammer ES, et al. Urinary 6-Sulphatoxymelatonin levels and risk of breast cancer in premenopausal women: the ORDET cohort. Cancer Epidemiol Biomarkers Prev. (2010)
    3. Celinski K, et al. Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans. J Physiol Pharmacol. (2011)
    4. Konturek PC, et al. Role of melatonin in mucosal gastroprotection against aspirin-induced gastric lesions in humans. J Pineal Res. (2010)
    5. Gonciarz M, et al. Plasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatonin. J Pineal Res. (2012)
    6. Rosenberg SI, et al. Effect of melatonin on tinnitus. Laryngoscope. (1998)
    7. Megwalu UC, Finnell JE, Piccirillo JF. The effects of melatonin on tinnitus and sleep. Otolaryngol Head Neck Surg. (2006)
    8. Hurtuk A, et al. Melatonin: can it stop the ringing. Ann Otol Rhinol Laryngol. (2011)
    9. Ochoa JJ, et al. Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. J Pineal Res. (2011)
    10. Samples JR, Krause G, Lewy AJ. Effect of melatonin on intraocular pressure. Curr Eye Res. (1988)
    11. Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev. (2002)
    12. Forsling ML, Wheeler MJ, Williams AJ. The effect of melatonin administration on pituitary hormone secretion in man. Clin Endocrinol (Oxf). (1999)
    13. Kostoglou-Athanassiou I, et al. Melatonin administration and pituitary hormone secretion. Clin Endocrinol (Oxf). (1998)
    14. Maldonado MD, et al. Melatonin administrated immediately before an intense exercise reverses oxidative stress, improves immunological defenses and lipid metabolism in football players. Physiol Behav. (2012)
    15. Koziróg M, et al. Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome. J Pineal Res. (2011)
    16. van Geijlswijk IM, et al. Evaluation of sleep, puberty and mental health in children with long-term melatonin treatment for chronic idiopathic childhood sleep onset insomnia. Psychopharmacology (Berl). (2011)
    17. Lemoine P, et al. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res. (2007)
    18. Luthringer R, et al. The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia. Int Clin Psychopharmacol. (2009)
    19. Alstadhaug KB, et al. Prophylaxis of migraine with melatonin: a randomized controlled trial. Neurology. (2010)
    20. Neri G, et al. Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: personal experience from a randomized controlled study. Acta Otorhinolaryngol Ital. (2009)
    21. Kandil TS, et al. The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease. BMC Gastroenterol. (2010)
    22. Rimmele U, et al. Melatonin improves memory acquisition under stress independent of stress hormone release. Psychopharmacology (Berl). (2009)
    23. Arangino S, et al. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am J Cardiol. (1999)
    24. Nishiyama K, et al. Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men. Am Heart J. (2001)
    25. Cagnacci A, et al. Influences of melatonin administration on the circulation of women. Am J Physiol. (1998)
    26. Cook JS, Sauder CL, Ray CA. Melatonin differentially affects vascular blood flow in humans. Am J Physiol Heart Circ Physiol. (2011)
    27. Mills E, et al. Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J Pineal Res. (2005)

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