Alertness is an aspect of wakefulness with hints of attention, and is the ability to interpret and maintain attention on different targets. Supplements that increase alertness tend to be anti-sleep or stimulatory agents.

This page features 7 unique references to scientific papers.

MUST GET: Supplement Stack Guides - Saving You Money & Time

The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Alertness
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
C Melissa officinalis
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
C Centella asiatica
C Melatonin
C Modafinil
C Synephrine
D Creatine


  1. Bloomer RJ, et al Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized, placebo controlled, cross-over study . Lipids Health Dis. (2009)
  2. Bloomer RJ, et al Dietary supplement increases plasma norepinephrine, lipolysis, and metabolic rate in resistance trained men . J Int Soc Sports Nutr. (2009)
  3. McCarthy CG, et al A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women . Nutr Metab Insights. (2011)
  4. Seifert JG, et al Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans . Int J Med Sci. (2011)
  5. Sale C, et al Metabolic and physiological effects of ingesting extracts of bitter orange, green tea and guarana at rest and during treadmill walking in overweight males . Int J Obes (Lond). (2006)
  6. Haller CA, et al Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions . Br J Clin Pharmacol. (2008)
  7. Stohs SJ, et al Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes . Int J Med Sci. (2011)

(Common phrases used by users for this page include examine alertness)

(Users who contributed to this page include )