Alertness is an aspect of wakefulness with hints of attention, and is the ability to interpret and maintain attention on different targets. Supplements that increase alertness tend to be anti-sleep or stimulatory agents.

This page features 14 unique references to scientific papers.

MUST GET: Supplement Stack Guides - Saving You Money & Time

The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Alertness
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
C Melissa officinalis
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
C Centella asiatica
C Melatonin
C Modafinil
C Synephrine
D Creatine


  1. Buguet A, et al Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. II. Effects on two nights of recovery sleep . J Sleep Res. (1995)
  2. Biederman J, et al Efficacy and safety of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, flexible-dose study . Pediatrics. (2005)
  3. Kalechstein AD, De La Garza R 2nd, Newton TF Modafinil administration improves working memory in methamphetamine-dependent individuals who demonstrate baseline impairment . Am J Addict. (2010)
  4. Chapotot F, et al Distinctive effects of modafinil and d-amphetamine on the homeostatic and circadian modulation of the human waking EEG . Psychopharmacology (Berl). (2003)
  5. Pigeau R, et al Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature . J Sleep Res. (1995)
  6. Baranski JV, Pigeau RA Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo . J Sleep Res. (1997)
  7. Schmaal L, et al Effects of modafinil on neural correlates of response inhibition in alcohol-dependent patients . Biol Psychiatry. (2013)
  8. Zack M, Poulos CX Effects of the atypical stimulant modafinil on a brief gambling episode in pathological gamblers with high vs. low impulsivity . J Psychopharmacol. (2009)
  9. Dean AC, et al Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans . J Stud Alcohol Drugs. (2011)
  10. Turner DC, et al Cognitive enhancing effects of modafinil in healthy volunteers . Psychopharmacology (Berl). (2003)
  11. Bruce J, et al Impact of armodafinil on cognition in multiple sclerosis: a randomized, double-blind crossover pilot study . Cogn Behav Neurol. (2012)
  12. Müller U, et al Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers . Neuropharmacology. (2013)
  13. Müller U, et al Effects of modafinil on working memory processes in humans . Psychopharmacology (Berl). (2004)
  14. Niepel G, et al Association of a deficit of arousal with fatigue in multiple sclerosis: effect of modafinil . Neuropharmacology. (2013)

(Common phrases used by users for this page include examine alertness)

(Users who contributed to this page include )