ADHD in Children

Attention deficit hyperactive disorder (ADHD) in children is currently being investigated from a nutraceutical perspective, and these supplements are thought to confer similar (but perhaps lesser in magnitude) benefits as methylphenidate.

This page features 56 unique references to scientific papers.

MUST GET: Supplement Stack Guides - Saving You Money & Time

The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect ADHD in Children
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Fish Oil
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
C Modafinil
C Ginkgo biloba
C L-Carnitine
C Phosphatidylserine
C Zinc


  1. Koehler K, et al Serum testosterone and urinary excretion of steroid hormone metabolites after administration of a high-dose zinc supplement . Eur J Clin Nutr. (2009)
  2. Sangthawan D, Phungrassami T, Sinkitjarurnchai W A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients . J Med Assoc Thai. (2013)
  3. Wadhwa N, et al Efficacy of zinc given as an adjunct in the treatment of severe and very severe pneumonia in hospitalized children 2-24 mo of age: a randomized, double-blind, placebo-controlled trial . Am J Clin Nutr. (2013)
  4. Lyckholm L, et al A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders . J Pain Palliat Care Pharmacother. (2012)
  5. Henkin RI, Martin BM, Agarwal RP Efficacy of exogenous oral zinc in treatment of patients with carbonic anhydrase VI deficiency . Am J Med Sci. (1999)
  6. Sayyah M, et al Evaluation of oral zinc sulfate effect on obsessive-compulsive disorder: a randomized placebo-controlled clinical trial . Nutrition. (2012)
  7. Blostein-Fujii A, et al Short-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: effects on plasma 5'-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitro . Am J Clin Nutr. (1997)
  8. Mantzoros CS, et al Zinc may regulate serum leptin concentrations in humans . J Am Coll Nutr. (1998)
  9. Najafabadi MM, et al Zinc sulfate for relief of pruritus in patients on maintenance hemodialysis . Ther Apher Dial. (2012)
  10. Bamford JT, et al Randomized, double-blind trial of 220 mg zinc sulfate twice daily in the treatment of rosacea . Int J Dermatol. (2012)
  11. Sharquie KE, Najim RA, Al-Salman HN Oral zinc sulfate in the treatment of rosacea: a double-blind, placebo-controlled study . Int J Dermatol. (2006)
  12. Göransson K, Lidén S, Odsell L Oral zinc in acne vulgaris: a clinical and methodological study . Acta Derm Venereol. (1978)
  13. Verma KC, Saini AS, Dhamija SK Oral zinc sulphate therapy in acne vulgaris: a double-blind trial . Acta Derm Venereol. (1980)
  14. Dreno B, et al Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris . Dermatology. (2001)
  15. Stewart-Knox BJ, et al Supplemented zinc does not alter mood in healthy older European adults--a randomised placebo-controlled trial: the Zenith study . Public Health Nutr. (2011)
  16. Arnold LE, et al Zinc for attention-deficit/hyperactivity disorder: placebo-controlled double-blind pilot trial alone and combined with amphetamine . J Child Adolesc Psychopharmacol. (2011)
  17. Sawada T, Yokoi K Effect of zinc supplementation on mood states in young women: a pilot study . Eur J Clin Nutr. (2010)
  18. Aquilani R, et al Normalization of zinc intake enhances neurological retrieval of patients suffering from ischemic strokes . Nutr Neurosci. (2009)
  19. Siwek M, et al Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study . J Affect Disord. (2009)
  20. Kilic M, et al The effect of exhaustion exercise on thyroid hormones and testosterone levels of elite athletes receiving oral zinc . Neuro Endocrinol Lett. (2006)
  21. Kilic M Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with oral zinc . Neuro Endocrinol Lett. (2007)
  22. Kelishadi R, et al Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome . Metab Syndr Relat Disord. (2010)
  23. Bao B, et al Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent . Am J Clin Nutr. (2010)
  24. Ganguly A, et al A randomized controlled trial of oral zinc in acute pneumonia in children aged between 2 months to 5 years . Indian J Pediatr. (2011)
  25. Prasad AS, et al Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress . Am J Clin Nutr. (2007)
  26. Rashidi AA, et al Effects of zinc supplementation on serum zinc and C-reactive protein concentrations in hemodialysis patients . J Ren Nutr. (2009)
  27. Rodondi A, et al Zinc increases the effects of essential amino acids-whey protein supplements in frail elderly . J Nutr Health Aging. (2009)
  28. Valentiner-Branth P, et al A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal . Am J Clin Nutr. (2010)
  29. Kara E, et al Effect of zinc supplementation on antioxidant activity in young wrestlers . Biol Trace Elem Res. (2010)
  30. Mansouri A, et al The effect of zinc sulfate in the prevention of high-dose chemotherapy-induced mucositis: a double-blind, randomized, placebo-controlled study . Hematol Oncol. (2012)
  31. Hashemipour M, et al Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children . Hormones (Athens). (2009)
  32. Arda HN, et al The role of zinc in the treatment of tinnitus . Otol Neurotol. (2003)
  33. Friel JK, et al Elevated intakes of zinc in infant formulas don not interfere with iron absorption in premature infants . J Pediatr Gastroenterol Nutr. (1998)
  34. Olivares M, et al Effect of increasing concentrations of zinc on the absorption of iron from iron-fortified milk . Biol Trace Elem Res. (2012)
  35. Olivares M, Pizarro F, Ruz M Zinc inhibits nonheme iron bioavailability in humans . Biol Trace Elem Res. (2007)
  36. Olivares M, Pizarro F, Ruz M New insights about iron bioavailability inhibition by zinc . Nutrition. (2007)
  37. Mun JH, et al Oral zinc sulfate treatment for viral warts: an open-label study . J Dermatol. (2011)
  38. Al-Gurairi FT, Al-Waiz M, Sharquie KE Oral zinc sulphate in the treatment of recalcitrant viral warts: randomized placebo-controlled clinical trial . Br J Dermatol. (2002)
  39. Sharquie KE, Khorsheed AA, Al-Nuaimy AA Topical zinc sulphate solution for treatment of viral warts . Saudi Med J. (2007)
  40. Tupe RP, Chiplonkar SA Zinc supplementation improved cognitive performance and taste acuity in Indian adolescent girls . J Am Coll Nutr. (2009)
  41. Dreno B, et al Low doses of zinc gluconate for inflammatory acne . Acta Derm Venereol. (1989)
  42. Sadeghian G, Ziaei H, Nilforoushzadeh MA Treatment of localized psoriasis with a topical formulation of zinc pyrithione . Acta Dermatovenerol Alp Panonica Adriat. (2011)
  43. Basnet S, et al A randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young children . Pediatrics. (2012)
  44. Shah GS, et al Role of zinc in severe pneumonia: a randomized double bind placebo controlled study . Ital J Pediatr. (2012)
  45. Seet RC, et al Oral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levels . Atherosclerosis. (2011)
  46. Valavi E, et al The efficacy of zinc supplementation on outcome of children with severe pneumonia. A randomized double-blind placebo-controlled clinical trial . Indian J Pediatr. (2011)
  47. Srinivasan MG, et al Zinc adjunct therapy reduces case fatality in severe childhood pneumonia: a randomized double blind placebo-controlled trial . BMC Med. (2012)
  48. Somi MH, et al Effects of low dose zinc supplementation on biochemical markers in non-alcoholic cirrhosis: a randomized clinical trial . Arch Iran Med. (2012)
  49. Arbabi-kalati F, et al Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: a double-blind randomized clinical trial . Arch Iran Med. (2012)
  50. Ertekin MV, et al Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study . Int J Radiat Oncol Biol Phys. (2004)
  51. Chandyo RK, et al Two weeks of zinc administration to Nepalese children with pneumonia does not reduce the incidence of pneumonia or diarrhea during the next six months . J Nutr. (2010)
  52. Uçkardeş Y, et al The effect of systemic zinc supplementation on oral health in low socioeconomic level children . Turk J Pediatr. (2009)
  53. Jalali GR, et al Impact of oral zinc therapy on the level of sex hormones in male patients on hemodialysis . Ren Fail. (2010)
  54. Netter A, Hartoma R, Nahoul K Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count . Arch Androl. (1981)
  55. Solati Z, et al Zinc monotherapy increases serum brain-derived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: A double-blind, randomized, placebo-controlled trial . Nutr Neurosci. (2014)
  56. Ranjbar E, et al Effects of zinc supplementation on efficacy of antidepressant therapy, inflammatory cytokines, and brain-derived neurotrophic factor in patients with major depression . Nutr Neurosci. (2014)

(Common phrases used by users for this page include bacopa monnieri pediatric trials)

(Users who contributed to this page include )