Yerba mate

Ilex paraguariensis, also known as yerba mate, is a tea brewed from a plant native to South America. It is a good source of Caffeine and contains bioactive compounds like Quercetin and Ursolic Acid.

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Ilex paraguariensis , commonly called yerba mate, is a flowering tree. Traditionally, its leaves are brewed into a stimulating tea, popular throughout the Middle East and South America.

Yerba mate is marketed for its supposed ability to suppress appetite and burn fat. Evidence suggests its appetite-suppression effect can only be achieved through high doses, if at all. Yerba mate’s fat burning effect is attributed to its Caffeine content. It has not been shown to be a more effective fat burner than compounds like Green Tea Catechins, though it can help reverse some of the adverse health effects associated with obesity.

Yerba mate has anti-inflammatory and anti-oxidant properties. It is able to reduce LDL cholesterol within 20 days of supplementation. Like many supplements derived from plants, it protects the heart and cardiovascular system.

Yerba mate contains a cocktail of xanthines (like Caffeine), flavonoids (like Quercetin), saponins (like Ursolic Acid), and cinnamic acid compounds (like Chlorogenic Acid).

Yerba mate is a healthy tea, but it is not necessarily healthier than other plant-based drinks, like coffee. It does, however, have a unique nutrient composition.

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Also Known As

Ilex paraguariensis, Mate plant, St. Hilaire, Aquifoliaceae


Things to Note

  • Preparing Yerba Mate tea with milk does not seem to negatively affect mineral absorption[1]

  • 1g/kg bodyweight oral dosing in rats may be approximately equal to 1.5 liters of prepared Yerba Mate tea[2]

Is a Form of


Goes Well With

  • Quercetin (increases anti-inflammatory potential of matesaponins)

Caution Notice

Examine.com Medical Disclaimer

Studies typically use a dose of 3 cups (330mL each) of yerba mate a day, for up to 60 days.

It’s safe to drink up to 1.5 liters of yerba mate a day, though toxicity has not been shown to occur from higher doses either.

A daily supplemental dose of isolated yerba mate in a powdered supplemental form is between 1,000-1,500mg of yerba mate leaf.


Although the notion that "Yerba Mate is a better stimulation than coffee" cannot be ruled out at this time, there is no evidence to support it either. The Matenosides are underresearched but may play a role (being unique to Yerba Mate consumption)


Kurtis Frank

The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what effect Yerba mate has in your body, and how strong these effects are.
GradeLevel of Evidence
ARobust research conducted with repeated double blind clinical trials
BMultiple studies where at least two are double-blind and placebo controlled
CSingle double blind study or multiple cohort studies
DUncontrolled or observational studies only
Level of Evidence
EffectChange
Magnitude of Effect Size
Scientific ConsensusComments
CMetabolic Rate

No significant influence on metabolic rate has been noted

CFat Oxidation

Minor

An increase in fat oxidation assessed via a lower respiratory quotient has been noted

CHeart Rate

Minor

A decrease has been noted with Yerba Mate consumption, which is somewhat notable as stimulants tend to increase heart rate

CBlood Pressure

No significant influences on blood pressure have been noted (although this may be due to it being underresearched; Mate may follow the same motifs as caffeine ingestion)

DGeneral Oxidation

Minor

A decrease in serum oxidative parameters tends to be noted following Mate consumption

DAnti-Oxidant Enzyme Profile

Minor

Appears to increase the primary three antioxidant enzymes (glutathione, catalase, and SOD) in both healthy and diseased persons

DLDL-C

Minor

Decreases in LDL cholesterol have been noted in metabolically unwell persons following moderate Mate consumption (as brewed tea)

DApolipoprotein B

Minor

Somewhat of a decrease in hyperlipidemic patients consuming Mate tea

DHDL-C

Minor

An increase in HDL-C has been noted with Mate consumption

DTotal Cholesterol

Minor

A decrease of total cholesterol has been noted with Mate consumption

DLipid Peroxidation

Minor

A decrease in lipid peroxidation has been noted with Mate consumption over 7 days

DHbA1c

Minor

A decrease in HbA1c levels has been detected in type II diabetics consuming Mate tea, although not to a remarkable degree

DBlood Glucose

Minor

A slight decrease in blood glucose has been noted with Mate consumption in type II diabetics; no evidence in otherwise healthy persons

DBone Mineral Density

Minor

An association has been noted with increased bone mineral density and Mate consumption; insufficient evidence to suggest a causative role as no interventions exist

DEsophageal Cancer Risk

Although associations exist between mate consumption and esophageal cancer risk, this appears to apply to any (scalding) hot beverage and is not associated with cooled... show


Studies Excluded from Consideration


Disagree? Join the Yerba mate Discussion

Table of Contents:


Edit1. Sources and Composition

1.1. Sources

Yerba Mate is a commonly used tea also known as Ilex paraguariensis, in which Ilex refers to the genus. Yerba Mate is a small shrub that grows up to 15 feet as a tree when aged, and bears small white flowers and red fruits. While the tree is the 'Mate' tree, the leaves are commonly referred to as Yerba; hence 'Yerba Mate' tends to be composed of the leaves from this plant.[4][5] The main producers and consumers of Yerba Mate tea are the countries of Argentina, Paraguay and Brazil.[5]

It is possible that crude yerba mate is more effective than commercial yerba mate, as one animal study investigating crude (drying the plant) against commercial (blanching, drying, milling, and aging) found the crude extract more potent.[6] This may be due to significantly higher levels of Caffeine and theobromine in the crude extract relative to commercial (1075.04±29.7ug/mL crude; 959.57±12.6 commercial) and saponin content (386.81±1.6ug/mL crude; 102.98±0.6 commercial).

In addition to the lower bioactive component quantities, the processing of Yerba Mate may also produce Polyaromatic Hydrocarbons; compounds formed from heating some molecules that are seen as carcinogenic.[7][8]

Its a plant that people make tea from the leaves. Some of the bioactives can be destroyed in processing though

1.2. Composition

As a herbal supplement, yerba leaves contains a variety of molecules including:

  • Flavonoids such as Quercetin, Kaempferol and Rutin, the latter at 6.10 ± 0.21mg/g dry weight,[9] although it varies on extraction[10]
  • Various (5+) cinnamic acids such as Caffeic, 3,4-dicaffeoylquinic acid, feruloylquinic acid, and Chlorogenic Acid, in which amounts of the latter can degrade by half through freeze drying (10.4 to 5.6mg/g dry weight)[9][11]
  • Caffeine (at around 17.5mg/g fresh weight Yerba Mate) and related xanthines[12]
  • 27+ different saponins, of which are combinations of Ursolic Acid, acetyl-ursolic acid, oleanolic acid as well as pomolic acid[13] These three in varying glycosides make up the majority of the saponin content[11] and make up about 3-10mg/g dry weight of the leaves.[14]
  • Megastigmane compounds, sometimes referred to as Matenosides[15]
  • Vitamin C[16]
  • Vitamin B1[16]
  • Vitamin B2[16]

The fruit of the Yerba Mate tree (not commonly used in teas) includes:

  • Matesaponins, usually ursolic acid and oleanolic acid although Ilexoside II (glycoside of pomolic acid) and brevicuspisaponin-1 (another pomolic acid compound) are also present in the fruit[17]

It should be noted that Yerba Mate is frequently referred to as possessing 'Matesaponins'; these are usually glycosides of ursolic acid (ursolic acid bound to sugars).[13][18] Matenosides also exist, and Matenoside A and B appear to refer to another class of Megastigmane compounds.[15]

The two classes of compounds above are referred to as the 'active' ingredients, although all classes found in Yerba appear to be significantly bioactive.

The fresh leaves of Yerba Mate have the highest polyphenolic and saponin content when compared to leaf extract of dried leaves, but still less overall phenols than Camellia Sinensis (Green Tea).[19] These two plants, however, have more polyphenols than a wide variety of other plants.[20] During Yerba Mate processing (consisting of blanching, drying, milling, and aging) saponin and xanthine content both appear to be significantly reduced (xanthines to 89% of original values, saponins to 27% of original value).[6]

In general, it would be good to think of Yerba Mate as the five compounds pictured above. Each compound represents a class (and there are most likely hundreds of compounds in Yerba Mate belonging to these classes), and each class tends to have similar biological effects


Edit2. Interactions with Body Fat

2.1. Adipogenesis

Yerba Mate appears to be able to inhibit adipocyte differentiation in vitro, and the compounds rutin (100ug/mL) and Chlorogenic Acid (300ug/mL) appear to contribute most potently to this effect.[9] Suppression was also noted on genes associated with adipogenesis (C/EBPα, PPARγ2, TNF-α) in which both rutin and CA were again the most potent.[9] These isolated compounds were more effective than leaf extracts (fresh and dried), suggesting that synergy between nutrients in Yerba Mate do not exist or apply to adipogenesis.[9]

A study in C57BL/6J mice using Yerba Mate at three doses (0.5, 1, and 2g/kg bodyweight) for 6 weeks significantly reduced food and water intake (seemingly dose dependent, but differences between doses not significant) [21]

Sounds nice, and may contribute to some of the soon-to-be-mentioned anti-obesity effects.

2.2. Metabolic Rate and Inducing Fat Loss

A study investigating 1.5g of Yerba Mate powder in a blinded manner found that there was no significant effect of Yerba Mate on the Metabolic Rate, although the respiratory quotient dropped indicating more fatty acids burnt for metabolic purposes over glucose.[22] A decrease in heart rate alongside no influences on blood pressure were noted.[22]

A rat study using high dose Yerba Mata (1g/kg bodyweight; human equivalent dose of 160mg/kg) found that after obesity was induced, consumption of Yerba Mate was able to reduce the state of obesity without influencing food intake.[23] Yerba Mate was able to greatly attenuate changes in adipose mRNA associated with obesity, including an attentuation of TNF-α, IL-6, Leptin, and CCR2 and CCL2. A significant rise in anti-obesity mRNA including PPARy2, Adiponectin, PCG-1α and UCP1 was noted, as well as a decreased macrophage infiltration of adipose.[24][23] Another rat study using 0.24%w/w Yerba Mate in the food during inducing obesity in rats was able to reduce final body weight by 10.7%, and food intake appeared to be reduced by 4.32%,[24] and attenuation of body weight gain and reversing of some negative health effects of obesity has been seen at lower dosages of 100mg/kg bodyweight as well (16mg/kg bodyweight human equivalent).[25]

Possibly related to improvements in mRNA of PGC-1α and PPARy2, it was noted that Yerba at 0.24%w/w of the diet was able to negate the suppression of AMPKα induced by obesity and cause a relative increase in protein content of AMPKα in adipose tissue.[24]

Interestingly, a study using up to 2g/kg bodyweight Yerba Mate in C57BL/6J mice found significant decreases in weight that could not solely be explained by the reduction of food intake noted;[21] body weight was significantly reduced after 1 week, but declined at a lesser rate beyond that until study cessation at 6 weeks. This curve mimicks the metabolic curve of Caffeine, in which fat burning becomes desensitized to after a week. Another study investigating lipase inhibition noted a similar curve for 1 week after Mate ingestion at similar dosages.[26]

A case can be made for fat burning effects of Yerba Mate to be due greatly to the xanthine component.[21] This is not to conflate overall weight loss, however, as Yerba Mate may inhibit nutrient uptake and reduce appetite (both of which would contribute to weight loss independent of metabolic rate)

Only human study using reasonable dosages showed no acute benefit, whereas the rat studies that did show benefit were more 'attenuate weight gain' rather than 'induce weight loss'; high dosages used as well

2.3. Appetite

It is theoretically possible that Yerba Mate can suppress appetite, due to its Caffeine content (a conditional appetite suppressant) and its ability to reduce gastric emptying after meals.[3] This appetite suppression has been noted in rats fed 50-100mg/kg bodyweight (human equivalent dose of 8-16mg/kg bodyweight), in which GLP-1 and leptin increases via caffeic compounds and the Yerba Mate saponins were credited.[27]

One human study using YGD capsules (Yerba Mate, Guarana, and Damiana) found that after 10 days of using 3 YGD capsules before major meals (3 capsules totalling 336mg Yerba, 285mg Guarana, 108mg Damiana) that placebo group lost 0.3+/-0.03kg and YGD lost 0.8+/-0.05kg.[3] When the study was extended to 45 days, the difference were a loss of 0.3+/-0.08kg (placebo) and 5.1+/-0.5kg (YGD).[3]

A 12 month maintenance period was done in an unblinded manner and without placebo, but it was found that continual ingestion of YGD capsules was able to maintain this weight loss.[3] No dietary records or excretory measures were taken (not even total dose of YGD daily), so a suppression in food intake or food absorption cannot be ruled out.

Other studies looking at the possibility of appetite suppression have varied. One study investigating HDL oxidation rates that did not instruct dietary changes found that, after 15 days supplementation, dietary intake was significant reduced from an average of 1706.9+/-414.8kcal daily to 1470.8+/-446.5kcal in a sample of 15 women; suggesting appetite suppression from 3 servings of 330mL yerba mate tea.[28] A larger scale study investigating Yerba Mate where diet was recorded, however, did not find statistically significant differences; the group instructed to 'eat more fruits, veggies and less bad fats' ate about 100kcal more than the group simply told to drink 1 liter of yerba mate tea daily.[29] A study on men (half with type II diabetes) also found a non-significant trend of decreased food consumption, but more minor than the previous study and around 50-100kcal with tea intervention.[30]

Its possible yerba mate suppresses appetite, but the studies aren't of a quality to support this view. The unblinded nature could have just steered participants away from a cookie, or the yerba tea could have made the ice cream taste bad.


Edit3. Interactions with Glucose Metabolism

3.1. Carbohydrate Absorption

Yerba Mate has been shown to decrease SLGT1 gene expression in the intestines after 1g/kg ingestion for 28 days in diabetic and non-diabetic rats.[31] This effect was hypothesized to be from the flavonoid content (of which includes Quercetin) and Chlorogenic Acid,[31] with variable degress of downregulation (53.8% and 19.3% reduction in upper small intestine activity of nondiabetic and diabetic rats, respectively; 26.6% and 46.2% reduction in middle small intestine, respectively).[31]

3.2. Obesity induced Diabetes

A study on C57BL/6J mice indicated that 2g/kg of Yerba Mate daily was able to bring abnormal blood glucose levels (induced by a high (60%) fat diet) to match control, and doses lower than that (0.5, 1g/kg) were able to attenuate the changes over 6 weeks.[21]

These results are not unanimous, as some studies do note no significant changes in blood glucose. One study using 1g/kg bodyweight Yerba Mate over 28 days noted no significant differences in glucose, insulin, or glucose-6-phosphatase activity in the liver in non-obese alloxan-induced diabetic rats.[31]

In humans, Yerba Mate tea (3 cups of 330mL daily) over a period of 60 days was able to decrease elevated blood glucose by 25mg/dL and reduce HbA1c by approximately 0.85%.[30]


Edit4. Interactions with Lipid Metabolism

4.1. Mechanisms

Yerba Mate, at 1-2g/kg bodyweight, has been shown to inhibit pancreatic lipase in mice.[26] In vitro analysis showed a dose-dependent increase in inhibition until Yerba Mate hit 3mg/mL, corresponding to 9mg of Yerba Mate extract per gram of enzyme substrate (in this case, fatty acids) and with a 79+/-1.3% inhibition.[26] Weight gain was attenuated with Mate, but fecal fat analysis was not conducted to assess fat malabsorption.[26] This lipase inhibition appears to be related to the matesaponins, and a pure water extract of yerba mate seems to be less effective in vitro (58%) than other extracts (88-95%) as the most potent lipase inhibitor are fat soluble.[32]

4.2. Anti-oxidation of Lipoproteins

An ex vivo study using blood from volunteers found that ingestion of Yerba Mate tea was able to reduce the rate of forced oxidation of LDL induced by copper, but was apparently ineffective at protecting LDL from oxidation induced by lipoxygenase or peroxynitrate.[33] This protection has also been seen in vivo with the HDL molecule in vitro[34] and after consumption of 5g instantized Yerba Mate in adult men.[28]

This protection from lipid peroxidation extends to polyunsaturated fatty acids, as a study in mice livers found reduced rates of PUFA oxidation with Yerba Mate at dosages starting at 0.5g/kg bodyweight and up to 2g/kg bodyweight.[35]

4.3. Interventions

An intervention study using 1 liter of Yerba Mate tea daily over a period of 90 days found that LDL cholesterol was significantly decreased (160mg/dL to 150mg/dL) in dyslipidemic women without any dietary changes needed.[29] This same study design was carried out in diabetic and pre-diabetic men to much the same effects, decreasing LDL-C and also improving parameters of glucose metabolism.[30] In both cases, the tea itself did not influence diet significantly yet the other groups fed yerba and given new diets fared better than the groups given yerba in isolation.[29][30]

The effects seen with Yerba Mate also appear to be additive to statin therapy, and may offer hope as a adjunct therapy.[36]

Studies that measure lipids over time (usually 20, 40, and 60 days after the start of the study) note a statistically significant improvement in parameters by 20 days, but no further significant improvements over time. Yerba's benefits on lipid parameters appear to manifest fast but may not culminate over time.[36][29][30]


Edit5. Interactions with Immunology and Inflammation

5.1. Mechanisms

Cinnamic compounds in Yerba Mate, the dicaffeoylquinic acids, suppress inflammation and NO release from macrophages (immune cells) by preventing NF-kB from translocating into the nucleus; particularly subunits p50 and p65.[37] The effect seen here (preventing iNOS activation in macrophages) is also seen with both the saponin fraction and the flavonoid fraction, synergistically.[38] The bioactive saponins appear to be oleanolic acid and perhaps pomolic acid, as ursolic acid shows little anti-inflammatory effects.[38]

Yerba Mate extract may also protect macrophages from cytotoxicity (death) induced by nitrosylation, with a potency greater than Green Tea and Red Wine.[39] Nitrosylation is a process by which superoxide radicals bind with Nitric Oxide (NO) to form peroxynitrate (OONO-) and damages cells that tend to form Nitric Oxide such as Macrophages or the endothelium.[40][41]

5.2. In vivo

When preloaded at a dose of 150mg/kg daily (225mL Yerba Mate tea human equivalent) Yerba Mate appears to be effective in reducing the inflammatory insult on lung tissue from cigarette smoke;[42] less immune cells are recruited and less pro-inflammatory cytokines (TNF-α) are seen when Yerba Mate is consumed.

Yerba Mate, at 1g/kg bodyweight in mice, also reduces the presence of macrophages in adipose tissue; of which their presence is correlated with the state of obesity.[23] This same dose has also been shown to reduce transcloation of NF-kB in mouse liver and skeletal muscle, which promotes anti-inflammatory effects and may ameliorate the state of insulin resistance associated with obesity.[43] Both studies note a decreased level of circulating pro-inflammatory factors IL-6 and TNF-α.[23][43]

Yerba Mate possesses anti-inflammatory effects, and its locations of action appear to be promising. Too soon to make conclusions on its effects in the body, however.


Edit6. Interactions with Cancer Metabolism

6.1. Epidemiology

A meta-analysis of four epidemiological studies on the association between Yerba Mate tea consumption and oro-pharyngeal and oral cancers found a weak but significant OR of 2.11 with a CI of 1.39–3.19.[44] Individual studies tend to show ORs around 1.5-3.[45][46]

The carcinogenicity of Mate is usually given to Hot Mate, and the thermal injury associated with drinking hot beverages to upper digestive tissue.[47][48][49] This is heavily based upon one case-control survey noting no associated with Yerba Mate per se and cancer, but an association with temperature.[50] This designation seems to be tentative waiting for further studies.[47]

Yerba Mate has been associated with cancers beyond the oral cavity (implicating factors beyond thermal trauma), being connected once to lung cancer in a case-control study of 996 persons over 6 years[51] with a 1.6-fold increase in lung risk associated with heavy mate drinking. It has once been implicated in bladder cancer with an OR of 2.2,[52] which extended to coffee and other teas as well; a case-control study from a population with high rats of bladder cancer, however, reported no association.[53]

This small increase in cancers beyond the upper digestive tract implies chemical carcinogens, and may be due to carcinogens (benzo(a)pyrene and Polyaromatic hydrocarbon compounds) produced as a heat by-product during Yerba Mate processing and preparation.[54][55] The content of heavy metals such as aluminum does not appear to be significant enough to warrant concern.[56][57]

Yerba Mate is repeatedly associated with upper digestive tract cancers, although the severity of this association is not overly alarming. It is most likely due to the heat at which Yerba Mate is traditionally consumed causing thermal damage, but chemical carcinogens cannot be ruled out right now


Edit7. Nutrient-Nutrient Interactions

7.1. Quercetin

Saponins from Yerba Mate, particularly oleanolic acid, have the ability to prevent iNOS activation and to inhibit COX-2 in macrophages in the presence of a pro-inflammatory insult; exerting an anti-inflammatory effect. This reaction is synergistically enhanced by Quercetin.[38] Luckily, there is a Quercetin component in Yerba Mate tea.

7.2. Caffeine

One study investigating learning in mice found that as it pertains to social memory, something in Yerba Mate (possibly rutin or kaempferol) is able to synergistically potentiate caffeine and make non-effective dosages of caffeine effective.[58]


Edit8. Safety and Toxicology

In a acute and chronic study using research animals (rats and rabbits), Yerba Mate at a dose of 2g/kg bodyweight in both species was not associated with any toxicological or biochemical changes of toxicity.[59]

References

  1. Binaghi MJ, Pellegrino NR, Valencia ME. Mineral bioaccessibility in yerba mate (Ilex paraguariensis St) infusions and mixtures with iron fortified milk. Arch Latinoam Nutr. (2011)
  2. Miranda DD, et al. Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice. Mutagenesis. (2008)
  3. Andersen T, Fogh J. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. J Hum Nutr Diet. (2001)
  4. Bracesco N, et al. Recent advances on Ilex paraguariensis research: minireview. J Ethnopharmacol. (2011)
  5. Heck CI, de Mejia EG. Yerba Mate Tea (Ilex paraguariensis): a comprehensive review on chemistry, health implications, and technological considerations. J Food Sci. (2007)
  6. Silva RD, et al. The effect of aqueous extract of gross and commercial yerba mate (Ilex paraguariensis) on intra-abdominal and epididymal fat and glucose levels in male Wistar rats. Fitoterapia. (2011)
  7. Vieira MA, et al. Occurrence of polycyclic aromatic hydrocarbons throughout the processing stages of erva-mate (Ilex paraguariensis). Food Addit Contam Part A Chem Anal Control Expo Risk Assess. (2010)
  8. Kamangar F, et al. High levels of carcinogenic polycyclic aromatic hydrocarbons in mate drinks. Cancer Epidemiol Biomarkers Prev. (2008)
  9. Gosmann G, et al. Phenolic Compounds from Maté (Ilex paraguariensis) Inhibit Adipogenesis in 3T3-L1 Preadipocytes. Plant Foods Hum Nutr. (2012)
  10. Validation of an LC Method for Polyphenol Assay in Extractive Solutions from Ilex paraguariensis (Mate)
  11. de Souza LM, et al. Comprehensive analysis of maté (Ilex paraguariensis) compounds: development of chemical strategies for matesaponin analysis by mass spectrometry. J Chromatogr A. (2011)
  12. Pomilio AB, Trajtemberg S, Vitale AA. High-performance capillary electrophoresis analysis of mate infusions prepared from stems and leaves of Ilex paraguariensis using automated micellar electrokinetic capillary chromatography. Phytochem Anal. (2002)
  13. Gosmann G, et al. Triterpenoid saponins from Ilex paraguariensis. J Nat Prod. (1995)
  14. Coelho GC, et al. Quantification of saponins in extractive solution of mate leaves (Ilex paraguariensis A. St. Hil.). J Med Food. (2010)
  15. Xu GH, et al. Two acetylated megastigmane glycosides from the leaves of Ilex paraguariensis. Arch Pharm Res. (2010)
  16. Bioactive compounds content of chimarrão infusions related to the moisture of yerba maté (Ilex Paraguariensis) leaves
  17. Peixoto MP, et al. LC-UV Assay Method and UPLC/Q-TOF-MS Characterisation of Saponins from Ilex Paraguariensis A. St. Hil. (Mate) Unripe Fruits. Phytochem Anal. (2011)
  18. Kraemer KH, et al. Matesaponin 5, a highly polar saponin from Ilex paraguariensis. Phytochemistry. (1996)
  19. Polyphenolic Compounds, Antioxidant Capacity, and Quinone Reductase Activity of an Aqueous Extract of Ardisia compressa in Comparison to Mate (Ilex paraguariensis) and Green (Camellia sinensis) Teas
  20. Dudonné S, et al. Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. J Agric Food Chem. (2009)
  21. Kang YR, et al. Anti-obesity and anti-diabetic effects of Yerba Mate (Ilex paraguariensis) in C57BL/6J mice fed a high-fat diet. Lab Anim Res. (2012)
  22. Martinet A, Hostettmann K, Schutz Y. Thermogenic effects of commercially available plant preparations aimed at treating human obesity. Phytomedicine. (1999)
  23. Arçari DP, et al. Antiobesity effects of yerba maté extract (Ilex paraguariensis) in high-fat diet-induced obese mice. Obesity (Silver Spring). (2009)
  24. Pang J, Choi Y, Park T. Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: potential role of AMPK in the visceral adipose tissue. Arch Biochem Biophys. (2008)
  25. Hussein GM, et al. Protective and ameliorative effects of maté (Ilex paraguariensis) on metabolic syndrome in TSOD mice. Phytomedicine. (2011)
  26. Martins F, et al. Maté tea inhibits in vitro pancreatic lipase activity and has hypolipidemic effect on high-fat diet-induced obese mice. Obesity (Silver Spring). (2010)
  27. Hussein GM, et al. Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: involvement of glucagon-like peptide-1. Biol Pharm Bull. (2011)
  28. Matsumoto RL, et al. Effects of mate tea (Ilex paraguariensis) ingestion on mRNA expression of antioxidant enzymes, lipid peroxidation, and total antioxidant status in healthy young women. J Agric Food Chem. (2009)
  29. Boaventura BC, et al. Association of mate tea (Ilex paraguariensis) intake and dietary intervention and effects on oxidative stress biomarkers of dyslipidemic subjects. Nutrition. (2012)
  30. Klein GA, et al. Mate tea (Ilex paraguariensis) improves glycemic and lipid profiles of type 2 diabetes and pre-diabetes individuals: a pilot study. J Am Coll Nutr. (2011)
  31. Oliveira DM, et al. Yerba Maté (Ilex paraguariensis) aqueous extract decreases intestinal SGLT1 gene expression but does not affect other biochemical parameters in alloxan-diabetic Wistar rats. J Agric Food Chem. (2008)
  32. Sugimoto S, et al. Brazilian natural medicines. III. structures of triterpene oligoglycosides and lipase inhibitors from mate, leaves of ilex paraguariensis. Chem Pharm Bull (Tokyo). (2009)
  33. Matsumoto RL, et al. Effects of maté tea intake on ex vivo LDL peroxidation induced by three different pathways. Nutrients. (2009)
  34. Menini T, et al. Protective action of Ilex paraguariensis extract against free radical inactivation of paraoxonase-1 in high-density lipoprotein. Planta Med. (2007)
  35. Martins F, et al. Consumption of mate tea (Ilex paraguariensis) decreases the oxidation of unsaturated fatty acids in mouse liver. Br J Nutr. (2009)
  36. de Morais EC, et al. Consumption of yerba mate ( Ilex paraguariensis ) improves serum lipid parameters in healthy dyslipidemic subjects and provides an additional LDL-cholesterol reduction in individuals on statin therapy. J Agric Food Chem. (2009)
  37. Puangpraphant S, et al. Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-κB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells. Mol Nutr Food Res. (2011)
  38. Puangpraphant S, de Mejia EG. Saponins in yerba mate tea ( Ilex paraguariensis A. St.-Hil) and quercetin synergistically inhibit iNOS and COX-2 in lipopolysaccharide-induced macrophages through NFkappaB pathways. J Agric Food Chem. (2009)
  39. Bixby M, et al. Ilex paraguariensis extracts are potent inhibitors of nitrosative stress: a comparative study with green tea and wines using a protein nitration model and mammalian cell cytotoxicity. Life Sci. (2005)
  40. Cantoni O, et al. Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage. Comp Biochem Physiol A Mol Integr Physiol. (2005)
  41. Hoeldtke RD, et al. Nitrosative stress, uric Acid, and peripheral nerve function in early type 1 diabetes. Diabetes. (2002)
  42. Lanzetti M, et al. Mate tea reduced acute lung inflammation in mice exposed to cigarette smoke. Nutrition. (2008)
  43. Arçari DP, et al. Anti-inflammatory effects of yerba maté extract (Ilex paraguariensis) ameliorate insulin resistance in mice with high fat diet-induced obesity. Mol Cell Endocrinol. (2011)
  44. Dasanayake AP, Silverman AJ, Warnakulasuriya S. Maté drinking and oral and oro-pharyngeal cancer: a systematic review and meta-analysis. Oral Oncol. (2010)
  45. De Stefani E, et al. Risk factors for laryngeal cancer. Cancer. (1987)
  46. Castelletto R, et al. Alcohol, tobacco, diet, mate drinking, and esophageal cancer in Argentina. Cancer Epidemiol Biomarkers Prev. (1994)
  47. Coffee, Tea, Mate, Methylxanthines and Methylglyoxal
  48. De Stefani E, et al. Mate drinking, alcohol, tobacco, diet, and esophageal cancer in Uruguay. Cancer Res. (1990)
  49. Victora CG, et al. Hot beverages and oesophageal cancer in southern Brazil: a case-control study. Int J Cancer. (1987)
  50. Rolón PA, et al. Hot and cold mate drinking and esophageal cancer in Paraguay. Cancer Epidemiol Biomarkers Prev. (1995)
  51. De Stefani E, et al. Mate drinking and risk of lung cancer in males: a case-control study from Uruguay. Cancer Epidemiol Biomarkers Prev. (1996)
  52. Non-alcoholic beverages and risk of bladder cancer in Uruguay
  53. Iscovich J, et al. Tobacco smoking, occupational exposure and bladder cancer in Argentina. Int J Cancer. (1987)
  54. Purcaro G, et al. Characterization of the yerba mate (Ilex paraguariensis) volatile fraction using solid-phase microextraction-comprehensive 2-D GC-MS. J Sep Sci. (2009)
  55. Abnet CC. Carcinogenic food contaminants. Cancer Invest. (2007)
  56. Gomes da Costa AM, et al. Fractionation of aluminum in commercial green and roasted yerba mate samples ( Ilex paraguariensis St. Hil.) and in their infusions. J Agric Food Chem. (2009)
  57. Bragança VL, Melnikov P, Zanoni LZ. Trace elements in different brands of yerba mate tea. Biol Trace Elem Res. (2011)
  58. Prediger RD, et al. Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory. J Ethnopharmacol. (2008)
  59. de Andrade F, et al. Safety assessment of yerba mate (Ilex paraguariensis) dried extract: results of acute and 90 days subchronic toxicity studies in rats and rabbits. Food Chem Toxicol. (2012)
  60. Conforti AS, Gallo ME, Saraví FD. Yerba Mate (Ilex paraguariensis) consumption is associated with higher bone mineral density in postmenopausal women. Bone. (2012)
  61. Szymańska K, et al. Drinking of maté and the risk of cancers of the upper aerodigestive tract in Latin America: a case-control study. Cancer Causes Control. (2010)

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