Rhamnus Nakaharai is a taiwanese medicine historically used for gastrointestinal ailments. It belongs to the Rhamnus species of plants of which variations are grown globally. Rhamnus Nakaharai is a source of various phytonutrients (plant based nutrients) particularly, it is a fairly good source of Quercetin.
Things to Note
Although the Rhamnus genus has a moderate amount of research on it, this particular subset does not have much direct research
Not enough information is known about Rhamnus Nakaharai to come to a conclusion on proper dosages.
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Rhamnus Nakaharai just appears to be a vessel for 3-O-Methylquercetin. It seems to be marketed as a test booster form a company, but I cannot find any information on it affecting testosterone levels.
Table of Contents:
- 1 Sources and composition
- 2 Interactions with Oxidation
Inflammation and Immunology
- 3.1 Mechanisms
- 4.1 Mechanisms
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1.1. Sources and History
Rhamnus Nakaharia (from the family Rhamnaceae) is a folk medicine originating in Taiwan that has been used to treat constipation, inﬂammation, malignant tumors, and asthma.
Rhamnus Nakaharai (RN) is a Taiwanese herbal medicine that contains:
The napthalenic compound 6-methoxysorigenin and various glycosides and acylates of the parent compound, such as alpha-sorinin although 6-methoxyorigenin appears to be isolated from the wood component of the herb
The compound 6-methoxyorigenin appears to have anti-oxidative effects in vitro, as well as the related compound Isotorachrysone, which share structural similarities. 6-methoxygenin outperformed Trolox (a research standard) on Metal-chelating and protecting from lipid peroxidation, and was slightly outperformed on a DPPH test. The IC50 of the metal chelating ability of 6-methoxyorigenin (615.90+/-5.79) was lesser than that of EDTA (127.92+/-6.27).
3-O-Methylquercetin has been found to suppress the inflammatory (Nitric Oxide mediated) response from LPS (research pro-inflammatory agent) in macrophages in vitro. 3-O-Methylquercetin was found to inhibit Nitric Oxide release, protein expression of iNOS (induced by inflammation) and mRNA translation of iNOS with IC50 values of 4.23uM, 4.36uM, and 6.53uM respectively.
3-O-Methylquercetin appears to be a selective PDE3 inhibitor with an IC50 of 1.6mM via competitive inhibition.
- Ng LT, Lin CC, Lu CM Antioxidative effects of 6-methoxysorigenin and its derivatives from Rhamnus nakaharai . Chem Pharm Bull (Tokyo). (2007)
- Lin CN, et al Novel antiplatelet naphthalene from Rhamnus nakaharai . J Nat Prod. (1995)
- Hsiao G, et al Antioxidant properties of isotorachrysone isolated from Rhamnus nakaharai . Biochim Biophys Acta. (1996)
- Jiang JS, et al Mechanisms of suppression of nitric oxide production by 3-O-methylquercetin in RAW 264.7 cells . J Ethnopharmacol. (2006)
- Ko WC, et al 3-O-methylquercetin more selectively inhibits phosphodiesterase subtype 3 . Planta Med. (2003)
- Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, et al Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial . JAMA. (2015)
- Taylor MJ1, et al Folate for depressive disorders . Cochrane Database Syst Rev. (2003)
- Godfrey PS1, et al Enhancement of recovery from psychiatric illness by methylfolate . Lancet. (1990)
- Kushwaha S1, Chawla P1, Kochhar A1 Effect of supplementation of drumstick (Moringa oleifera) and amaranth (Amaranthus tricolor) leaves powder on antioxidant profile and oxidative status among postmenopausal women . J Food Sci Technol. (2014)
(Common misspellings for Rhamnus nakaharai include ramnus, rhamus, rhamnis, rhamis, ramnis, nakahara, nakahari)
(Editors who contributed to this page include KurtisFrank )