Rhamnus nakaharai

Rhamnus Nakaharai is a herb that has been used as folk medicine in Taiwan for intestinal distress (mostly constipation) and asthma, it is a good source of Quercetin glycosides but not much research exists on the herb per se.

This page features 5 unique references to scientific papers.

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Rhamnus Nakaharai is a taiwanese medicine historically used for gastrointestinal ailments. It belongs to the Rhamnus species of plants of which variations are grown globally. Rhamnus Nakaharai is a source of various phytonutrients (plant based nutrients) particularly, it is a fairly good source of Quercetin.

Things to Note

  • Although the Rhamnus genus has a moderate amount of research on it, this particular subset does not have much direct research

Rhamnus Nakaharai just appears to be a vessel for 3-O-Methylquercetin. It seems to be marketed as a test booster form a company, but I cannot find any information on it affecting testosterone levels.

Kurtis Frank

Table of Contents:

1. Sources and composition

1.1. Sources and History

Rhamnus Nakaharia (from the family Rhamnaceae) is a folk medicine originating in Taiwan that has been used to treat constipation, inflammation, malignant tumors, and asthma.[1]

1.2. Composition

Rhamnus Nakaharai (RN) is a Taiwanese herbal medicine that contains:

  • The napthalenic compound 6-methoxysorigenin and various glycosides and acylates of the parent compound, such as alpha-sorinin[1] although 6-methoxyorigenin appears to be isolated from the wood component of the herb[1]
  • Isotorachyrsone and derivatives.[2][3]
  • Quercetin glycosides, specifically 3-O-Methylquercetin.[2][4]

2. Interactions with Oxidation

The compound 6-methoxyorigenin appears to have anti-oxidative effects in vitro,[1] as well as the related compound Isotorachrysone, which share structural similarities.[3] 6-methoxygenin outperformed Trolox (a research standard) on Metal-chelating and protecting from lipid peroxidation, and was slightly outperformed on a DPPH test.[1] The IC50 of the metal chelating ability of 6-methoxyorigenin (615.90+/-5.79) was lesser than that of EDTA (127.92+/-6.27).[1]

3. Inflammation and Immunology

3.1. Mechanisms

3-O-Methylquercetin has been found to suppress the inflammatory (Nitric Oxide mediated) response from LPS (research pro-inflammatory agent) in macrophages in vitro.[4] 3-O-Methylquercetin was found to inhibit Nitric Oxide release, protein expression of iNOS (induced by inflammation) and mRNA translation of iNOS with IC50 values of 4.23uM, 4.36uM, and 6.53uM respectively.[4]

4. Intestinal Interactions

4.1. Mechanisms

3-O-Methylquercetin appears to be a selective PDE3 inhibitor with an IC50 of 1.6mM via competitive inhibition.[5]


  1. Ng LT, Lin CC, Lu CM Antioxidative effects of 6-methoxysorigenin and its derivatives from Rhamnus nakaharai . Chem Pharm Bull (Tokyo). (2007)
  2. Lin CN, et al Novel antiplatelet naphthalene from Rhamnus nakaharai . J Nat Prod. (1995)
  3. Hsiao G, et al Antioxidant properties of isotorachrysone isolated from Rhamnus nakaharai . Biochim Biophys Acta. (1996)
  4. Jiang JS, et al Mechanisms of suppression of nitric oxide production by 3-O-methylquercetin in RAW 264.7 cells . J Ethnopharmacol. (2006)
  5. Ko WC, et al 3-O-methylquercetin more selectively inhibits phosphodiesterase subtype 3 . Planta Med. (2003)

(Common misspellings for Rhamnus nakaharai include ramnus, rhamus, rhamnis, rhamis, ramnis, nakahara, nakahari)

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