Rauwolscine is a molecule which is very similar in structure to Yohimbine, and probably similar in its effects as well; may be more potent, but limited evidence exists
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Rauwolscine is what is known as a diastereoisomers of Yohimbine. There are 3 diastereoisomers, the other two being corynanthine and 3-epi-alpha-yohimbine. Basically, it is an alternate form of it with slightly altered properties.
It's mechanisms of action are very similar to yohimbine, as it can act as an Alpha(2)Adrenergic antagonist and thus aid in fat burning (not so much by inducing fat loss, but by alleviating pressures the body exerts to preserve fat mass; its like preventing the body from stopping the fat loss, but doesn't induce it directly). Rauwolscine shows some promise in being more effective due to higher potency on the same receptor.
It also shares the same aphrodisiac and mood-elevating effects as yohimbine, although the potency on this relative to yohimbine is not known.
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Alpha-yohimbine, isoyohimbine
Rauwolscine has more potent MAO inhibitory effects than does Yohimbine, and the same cautions of pairing monoamines with an MAO extend to Rauwolscine with a bit more weight.
Examine.com Medical DisclaimerNot enough information is known at the moment for a recommended dose.
Not enough info is known for an active oral dose, but a good place to start (if you choose to) would be around yohimbine's dosages; 15mg in combination with other fat loss supplements or 50mg in isolation.
I like the lower dosage for both efficacy and covering my ass ;)
Kurtis Frank
Rauwolscine, or {3H}Rauwolscine, is a potent and selective antagonist of alpha-2 adrenergic receptors.[1] This is the same mechanism by which yohimbine acts.
{3H}Rauwolscine is less potent than Yohimbine in protecting against adrenaline-induced blood pressure increases (both of which were less potent than corynanthine and more potent than 3-epi-alpha-yohimbine), this effect seems related to their affinity for the alpha-2 adrenoreceptor.[2]
Like yohimbine, rauwolscine is an agonist of 5-HT1a/b receptors and induce serotonin-like effects. While yohimbine has more affinity for the receptor, rauwolscine has a lower IC50 value (meaning it can saturate more receptors at the same dose) and can be seen as slightly more potent in serotonergic activity.[3][4]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor|published=1998 Jan|authors=Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL|journal=Naunyn Schmiedebergs Arch Pharmacol]
(Common phrases used by users for this page include rawloscine, rauwolscine supplement benefits, rauwolscine supplement, rauwolscine scientific, Rauwolscine effect on the body, "supplement that acts as alpha agonist")
(Users who contributed to this page include KurtisFrank, Sol)
