Rauwolscine

Rauwolscine is a molecule which is very similar in structure to Yohimbine, and probably similar in its effects as well; may be more potent, but limited evidence exists.

This page features 4 unique references to scientific papers.


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Rauwolscine is what is known as a diastereoisomers of Yohimbine. There are 3 diastereoisomers, the other two being corynanthine and 3-epi-alpha-yohimbine. Basically, it is an alternate form of it with slightly altered properties.

It's mechanisms of action are very similar to yohimbine, as it can act as an Alpha(2)Adrenergic antagonist and thus aid in fat burning (not so much by inducing fat loss, but by alleviating pressures the body exerts to preserve fat mass; its like preventing the body from stopping the fat loss, but doesn't induce it directly). Rauwolscine shows some promise in being more effective due to higher potency on the same receptor.

It also shares the same aphrodisiac and mood-elevating effects as yohimbine, although the potency on this relative to yohimbine is not known.

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Also Known As

Alpha-yohimbine, isoyohimbine


Do Not Confuse With

Yohimbine


Things to Note

  • Rauwolscine is highly stimulatory and may also be mood-elevating.

Is a Form of


Goes Well With

  • Adrenaline increasing compounds like Caffeine

Does Not Go Well With

  • Insulin spikes and food intake (extrapolation from Yohimbine)

Caution Notice

Rauwolscine has more potent MAO inhibitory effects than does Yohimbine, and the same cautions of pairing monoamines with an MAO extend to Rauwolscine with a bit more weight.

Examine.com Medical Disclaimer

There is insufficient information for recommending a dosage of rauwolscine, although usually the dosing of Yohimbine supplementation is extrapolated onto rauwolscine.


Not enough info is known for an active oral dose, but a good place to start (if you choose to) would be around yohimbine's dosages; 15mg in combination with other fat loss supplements or 50mg in isolation.

I like the lower dosage for both efficacy and covering my ass ;)


Kurtis Frank

Table of Contents:


Edit1. Fat-Burning Potential

Rauwolscine, or {3H}Rauwolscine, is a potent and selective antagonist of alpha-2 adrenergic receptors.[1] This is the same mechanism by which yohimbine acts.


Edit2. Blood Vessel and Cardiac Health

{3H}Rauwolscine is less potent than Yohimbine in protecting against adrenaline-induced blood pressure increases (both of which were less potent than corynanthine and more potent than 3-epi-alpha-yohimbine), this effect seems related to their affinity for the alpha-2 adrenoreceptor.[2]


Edit3. Serotonergic Effects

Like yohimbine, rauwolscine is an agonist of 5-HT1a/b receptors and induce serotonin-like effects. While yohimbine has more affinity for the receptor, rauwolscine has a lower IC50 value (meaning it can saturate more receptors at the same dose) and can be seen as slightly more potent in serotonergic activity.[3][4]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor|published=1998 Jan|authors=Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL|journal=Naunyn Schmiedebergs Arch Pharmacol]

References

  1. Perry BD, U'Prichard DC. (3H)rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol. (1981)
  2. Rockhold RW, Gross F. Yohimbine diastereoisomers: cardiovascular effects after central and peripheral application in the rat. Naunyn Schmiedebergs Arch Pharmacol. (1981)
  3. Arthur JM, Casañas SJ, Raymond JR. Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors. Biochem Pharmacol. (1993)
  4. [3H

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