Myricetin

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Myricetin is a Bioflavonoids found in a myriad of foods and is exceptionally high in walnuts and red wine.

Although a lack of in vivo (in living) studies exist at this point in time, the in vitro (in cell culture) evidence looks to be promising for myricetin as an anti-cancer, anti-diabetic, and anti-osteoporotic agent.

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At the moment little is known for a recommended dose of Myricetin. Although effects have been noted at an established 1mg/kg BW per day.

Edit1. Glucose Metabolism and Anti-Diabetic Properties

In studies done in rats with injected myricetin, it has been noted that myricetin decreases blood glucose levels in a dose-dependent manner and ameliorates the adverse effects of metabolic syndrome during co-ingestion.^[1][2] The mechanism of action appears to be through potentiating insulin-dependent GLUT4 translocation via phosphatidylinositol 3-kinase (PI3K) and insulin receptor substrate-1 (IRS-1), although it has also been shown to improve blood glucose uptake independent of insulin.^[3]

Similar to Kaempferol, myricetin seems to be able to reduce blood glucose levels by increasing myocyte uptake as well as increasing hepatic glycogen synthesis.^[4]

The latter study was also via injection, and noted enhanced hepatic glycogen synthesis. Effects were noted at concentrations of 0.1uM-10.0uM, which correlated into an effective dose of 1.0mg/kg BW.

Edit2. Bone Metabolism

In vitro studies suggest that myricetin is able to prevent oxidative damage in osteoblasts and potentially protect against osteoporosis by this mechanism and others (such as increased calcium deposition). This effect was noted at a concentration of 20uM.^[5]

Edit3. Fat Metabolism

Myricetin, like the Bioflavonoids Quercetin and catechin-gallate (one of the four catechins of Green Tea) have been shown to inhibit glucose uptake into cultured rat adipocytes; the opposite effect as is seen in myocytes.^[6]

Edit4. Myricetin and Estrogen

Myricetin has the ability to agonize the estrogen receptor ER-alpha directly. It competes with 17b-estradiol for activation of the receptor in a concentration dependent manner and exerts slightly less potent estrogenic effects via the receptor agonism.^[7]

Edit5. Effects on Cancer: A Possible Anti-Carcinogen

Myricetin has been correlated with a decreased risk of prostate cancer^[8] in epidemiological studies and with an decreased risk of pancreatic cancer alongside the bioflavonoids Kaempferol and Quercetin.^[9]

References

1. Liu IM, et al. Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Med. (2007)
2. Liu IM, et al. Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats. Life Sci. (2007)
3. Liu IM, et al. Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med. (2005)
4. Ong KC, Khoo HE. Effects of myricetin on glycemia and glycogen metabolism in diabetic rats. Life Sci. (2000)
5. Lee KH, Choi EM. Myricetin, a naturally occurring flavonoid, prevents 2-deoxy-D-ribose induced dysfunction and oxidative damage in osteoblastic MC3T3-E1 cells. Eur J Pharmacol. (2008)
6. Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes
7. The red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor {alpha} in human breast cancer cells
8. Flavonoid intake and risk of chronic diseases
9. Flavonols and Pancreatic Cancer Risk

(Common misspellings for Myricetin include myrcetin, myrictin)

(Common phrases used by users for this page include right dose of myricetin, myricitrin antidiabetic, myricetin concentration, myricetin cancer, myricetin benefits blood sugar, Myrecetin)

(Users who contributed to this page include KurtisFrank, Sol)