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Zingiber officinale Roscoe, Zingiberaceae
Curcumin (other bioactive of the Zingiberaceae family)
Typically, dosages of 1-3g are used as a preventative treatment for nausea. This applies to morning sickness in pregnancy, motion sickness, and sometimes chemotherapy or operation-induced nausea.
For other usages of ginger, 1g is typically used. This seems to be effective for increasing intestinal motility, but was insufficient in reducing blood glucose in the one study attempting it.
For testosterone boosting, a supplement is probably advised. The dosage used in rats, after conversion to humans based on Body Surface Area, equates to about 14g from natural sources (usually less of an extract percentage than is possible with supplements).
Ginger can be ingested via several ways, and the following is an approximate standardization table for 1g of Ginger Extract:
The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what effect Ginger has in your body, and how strong these effects are.
|Grade||Level of Evidence|
|A||Robust research conducted with repeated double blind clinical trials|
|B||Multiple studies where at least two are double-blind and placebo controlled|
|C||Single double blind study or multiple cohort studies|
|D||Uncontrolled or observational studies only|
|Level of Evidence ||Effect||Change||Magnitude of Effect Size ||Scientific Consensus||Comments|
There appears to be a reliable and fairly notable decrease in nausea symptoms with 1-3g of ginger related to pregnancy and seasickness (not as much consensus for post-operative... show
|B||Rate of Gastric Emptying|
Ginger appears to increase the rate of gastric digestion, although the potency thereof is not too reliable
|B||Symptoms of Osteoarthritis|
There may be a small reducing effect, but it does not appear to be greater than the active control of Ibuprofen
Inflammatory parameters seem to be reduced following ginger consumption
|C||Colon cancer risk|
May reduce colon cancer risk as assessed by a beneficial influence in eicosanoids in the colon; requires more evidence
|C||Lower Esophageal Pressure|
A decrease in LES pressure (not necessarily a good thing, especially for acid reflux) has been noted with ginger ingestion
A possible reduction of delayed onset muscle soreness, but this topic is a bit contested
Possible cholesterol reducing effects associated with ginger consumption
May increase HDL-C levels
May decrease LDL-C
May decrease triglycerides
Ginger was capable of reducing menstrual pain at 1g daily
|C||Rate of Perceived Exertion|
No significant influence on the rate of perceived exertion
Despite the reduction in nausea associated with ginger consumption, it does not appear to be associated with reduced symptoms of motion sickness
May reduce symptoms of vertigo related to the anti-nausea effects, but this research is highly preliminary
No significant influence on pathological involuntary eye movements
An increase in memory has been noted in older women, no current studies in youth
A decrease in reaction time has been noted to be secondary to improvements in cognition in older women; no studies in youth at this moment in time.
A decrease in appetite has been noted with ginger intake
No significant alterations in blood glucose seen with ginger ingestion
No significant alterations in insulin levels (fasting) seen with ginger
|D||Thermic Effect of Food|
Ginger has been found to increase the thermic effect of coingested food products
Despite an increase in the thermic effect of food, overall metabolic rate does not appear affected
In infertile men, an undisclosed amount of ginger for three months is able to increase ejaculate volume by an average of 36.1%
An increase in testosterone has been noted to reach 17.7% in infertile men given an undisclosed amount of ginger over three months.
A 17.6% increase in follicle stimulating hormone has been noted in infertile men given ginger, which is thought to underlie the observed pro-seminal effects of supplementation.
Although the study is limited by lack of placebo control and disclosure of dosage, ginger is associated with a 43.2% increase in serum luteinizing hormone over three months... show
A somewhat minor increase in sperm count (16.2%) is seem with supplementation of ginger (amount undisclosed) to infertile men over three months.
Seminal viability (40.7%) and normal morphology () is increased in infertile men given ginger.
Preliminary evidence suggests a 47.3% increase in seminal motility seen with three months supplementation of ginger to infertile men.
|D||Anti-Oxidant Enzyme Profile|
An increase in seminal glutathione has been noted to reach 26.7% in otherwise infertile men.
In the semen of infertile men, the reduction in lipid peroxidation has reached 53.7% with supplementation of ginger over three months.
Ginger is the common name for the root of Zingiber officinale Roscoe, a plant that has historical precedence as both medicine and spice and is one of the more commonly used spices in the world. Historical uses for ginger include headaches and migraines, blood pressure and flow, and colds.
The most commonly consumed part of ginger is the rhizome, or the vertical portion of the root.
The ginger root contains 14 main bioactives:
Other compounds, found in many plants, are also found in Ginger Root:
The total phenolic content of ginger has at one time been calculated to be 157mg/100g fresh weight rhizome and 291mg/100g fresh weight leaves. The total flavonoid content appears to be 5.54-11.4mg/g dry weight, which is above that of Garlic, onions, papaya, black tea and semambu leaves all by at least two-fold. The flavonoid content seems to shift from the leaves to the rhizome during aging, with more mature plants localizing the nutrients to the rhizome.
6-Gingerol has been noted to be partially subject to glucuronidation, with the UGT1A1, 2B7 and 1A3 enzymes mediating conversion into a phenolic derivative while UGT1A9 mediated conversion into an alcohol derivative.-gingerol|published=2006 Nov 15|authors=Pfeiffer E1, Heuschmid FF, Kranz S, Metzler M|journal=J Agric Food Chem]
When looking at the serotonin receptors, it appears that many compounds in ginger have affinity for the 5-HT2B receptor including 8-Shogaol (Ki value of 1.8µM), 10-Gingerol (4.2µM), 10-Dehydrogingerdion (7.6µM), 10-Gingerdione (12.5µM), and 8-Gingerol (25.4µM).
There appears to be weak affinity (greater than 10µM) for the 5-HT2C receptor from most ginger phenolics except for 8-Shogaol, which has a Ki of 3.8µM.
The basic ginger phenolics have failed to demonstrate affinity for the 5-HT6 receptor in vitro.
2g of Ginger, taken with a meal, can slightly but significantly reduce the sensation of hunger and subsequent caloric intake (with no effect on satiety).
Oral doses of 400-800mg Ginger extract (7.3% 6-gingerol, 1.34% 6-shogaol) to otherwise healthy women (aged 54+/-3.57) over a period of 2 months was associated with an increaes of N100 amplitude and P300 amplitude (event-related potentials) at the 800mg dose and both doses, respectively. This study also noted, more practically, showed improvements (accuracy and speed) in word recognition tests and working memory (numeric and spatial) as well as improved choice reaction times.
In rats subject to right middle cerebral artery occlusion (MCAO) Ginger at 100, 200, and 300mg/kg and noted that ginger at all doses was able to improve the rate of spatial memory improvement after occlusion by 7 days, improving up to 21 days. This study also used Piracetam as an active control at 250mg/kg, and Piracetam was quicker at returning spatial memory after occlusion, and no tested drug influenced retention time. Both Piracetam and the two lower doses of ginger were effective in increasing hippocampal neuronal density after 21 days, but to a lesser extent than Aricept (another positive control drug). In regards to brain infarct size after occlusion, Ginger at 200mg/kg was more effective than all positive controls at reducing the size of infarct after occlusion despite not being significantly better at preserving levels of endogenous anti-oxidant enzymes.
Ginger, via its actions as a serotonin receptor antagonist, can increase insulin release from INS-1 cells, a research cell line for pancreatic beta-cells. Serotonin normally suppresses insulin release in these cells, and antagonizing the 5-HT(3) receptor can alleviate this suppression and lead to a reduction in blood glucose; the reduction may be up to 35% in rats and shows some effects in type I diabetic rats as well, despite less beta-cells. 1g of ginger root, taken orally in healthy humans, seems to be ineffective in significantly reducing blood glucose (showing non-significant trends) but can alleviate some of the effects of high blood sugar, such as reduced gastric motility.
At least one study has noted that Ginger, when taken at 2g alongside a (mostly carbohydrate) meal, is able to increase the caloric expenditure over the next 6 hours from that meal. Consumption of 2g ginger was associated with an average 43+/-21kcal increase in metabolic rate among a sample of 10 men and relative to no ginger. Overall metabolic rate independent of food was not affected.
May enhance the thermic effect of food, and increase metabolic rate (slighty; 43+/-21 calories) in the context of a large meal
It appears to exert these effects gastrically rather than neurally, and can speed up gastric digestion, although the increase in motility is not the mechanism by which it alleviates nausea.
Due to interactions with the GI tract, many side-effects of taking nausea occur here; usually slight gastrointestinal complications after ingestion.
Ginger ingestion may have the ability to speed up gastric (stomach) transit of foods. It shows most benefit during states in which gastric motility would normally be suppressed, such as during sickness (nausea), hyperglycemia or disease state. It can occur in healthy persons via stimulating antral contractions, but due to being less potent it bridges statistical significance, with some positive and negative results. The effects of ginger on gastric motility appear to be independent of a meal.
A study on ginger and its effects on the Lower Esophageal Sphincter (LES) found that 1g of ginger was able to reduce LES pressure, which may exacerbate negative effects of heartburn in susceptible persons.
Ginger is known as having a 'carminative' effect, which is to break up and expel intestinal gas; it has traditionally been used to treat flatulence and gas.
This effect may be due to lowering of the lower esophageal sphincter above the stomach, which may cause gas produced in the stomach to leave orally rather than rectally.
Its effects on morning sickness, at a dose of 1g, either parallels that of 75mg Vitamin B6 or is slightly more effective. At least one study that upped the dosage of Ginger to 1,950mg found that it was more effective than 75mg Vitamin B6, however. Ginger is approximately as effective as metoclopramide (pharmaceutical), if not slightly less effective. When compared to dimenhydrinate, ginger appears to have a delayed time to effectiveness (in which dimenhydrinate is more effective for the first two days, then the differences are insignificant) whereas it does not have the drowsiness associated with Dimenhydrinate.
The research on nausea in general can quite reliably be extrapolated to alleviating nausea associated with pregnancy, and ginger appears to be effective. As to whether it is safe or not for pregnancy, short term (4 week or less) usage appears to be safe from obvious side-effects with longer usage unknown
Ginger has twice been shown to reduce the pain associated with periods in women at a dose of 1g daily, both times when taken as four divided dosages of 250mg. It is as effective as ibuprofen and mefenamic acid in this regard.
An aqueous extract of Ginger (600mg/kg bodyweight) has been found to increase serum testosterone, weight of testes, and testicle cholesterol content in otherwise healthy rats. Another study using dosages of 500mg/kg and 1g/kg bodyweight found dose-dependent increases in seminal quality as well as dose-dependent increases in testosterone, from around 0.3nmol/L at baseline nearing 0.6nmol/L after 14 days with minimal differences existing between 14 and 28. Testosterone increasing effects have been reported in rats as low as 100mg/kg bodyweight (powdered extract), with control at 1.60±0.091ng/mL to 3.71±0.387ng/mL at 100mg/kg daily. There were increases in testosterone at 50mg/kg daily in this study, but it did not reach statistical significance.
Although testicle size increased after 14 and 28 days supplementation, this may be due to hypertrophy of the epididymus. Seminal sacs and the prostate were unchanged. After gavage feeding of 2000mg/kg per day for 35 days (very high dose) there appears to be decreases in testicle size and weight. This was hypothesized by the authors to be due to a negative feedback reaction from androgenic activity.
Gingerol has been implicated in preventing downstream signalling of testosterone involving prostate hypertrophy, as seen in LNCaP cells where gingerol incubation reduces prostate-specific antigen secretion induced from testosterone (up to 21%). Gingerol also induced apoptosis in these cells, and was able to reduce the increase in prostate size associated with testosterone in experimental animals.
In studies where damage occurs to reproductive organs, ginger shows efficacy in preventing oxidative damage induced by aluminum chloride and alleviate the reduction in sexuality associated with diabetes. Twice ginger has been implicated in reducing cisplatin induced testicular damage.
The mechanisms of ginger on testosterone are not really known. Past letters (in response to trials) suggest it may be via thromboxane inhbition, an effect shared between ginger and the reference drug cimetidine. However, Cimetidine appears to be an anti-androgen (opposite that of ginger) and this theorized mechanism of action may not be legitimate.
Ginger appears to be effective in increasing testosterone concentrations in rodents
In a study of infertile men, the improvements in fertiliy and seminal parameters observed with three months of therapy was associated with a 17.7% increase in testosterone concentrations; dosage of ginger used was not specified.
Preliminary evidence to support the usage of ginger to boost testosterone concentrations, although this has only been demonstrated in infertile men at this point in time
One study assessing a variety of medical plants for estrogenic properties noted that Ginger was able to activate the estrogen receptor in a yeast assay with an EC50 of 77.26ug/mL when the 95% ethanolic extract was tested; a similar potency to Glycyrrhiza Uralensis.
Supplementation of ginger to infertile men (3 months of therapy, dosage not specified) appears to be able to increase sperm count (16.2%), motility (47.3%), viability (40.7%), normal morphology (18.4%), and ejaculate volume (36.1%) paired with reductions in lipid peroxidation as assessed by MDA (53.7%) and increases in glutathione 26.7%).
5-HTP is the amino acid precursor to serotonin, a neurotransmitter commonly associated with happiness and contentment.
Ginger has actions as a serotonin receptor antagonist, of which many are located in the intestines. These effects seem to be mediated through gingerols and their metabolites.
Oral treatment of ginger (as juice) has been shown in rats to negate the hyperglycemia induced by serotonin; this hyperglycemia normally occurs as serotonin suppresses insulin secretion, and inhibiting this reaction causes a relative reduction in blood glucose.
As the serum levels of gingerols in the brain appears to be ten-fold lower than the level in the intestines and stomach after ingestion, it seems that, practically, this antagonism may only be relevant to serotonin's gastrointestinal and systemic interactions.
May counteract any intestinal action of serotonin and its precursor, and thus combination would not be advised. May not adversely interact with neural actions of serotonin due to too low a dose used.
Magnolia officinalis, or Magnolia Bark, is a herbal product which is typically reduced to its two active ingredients 'Magnolol' and 'Honokiol'; its effects on anti-depression (at 20mg/kg bodyweight combined) are synergistically enhanced when coingested with ginger at 14mg/kg bodyweight in rats despite ginger having no anti-depressive effects in isolation.
In meta-analysis' and reviews conducted on the topic, side-effects reported in clinical trials appear to be related to gastrointesinal discomfort and never more severe. These occur infrequently at the recommended 1-2g dosage range for Nausea prevention.
Studies in rats suggest that, when fed orally (gavage) there are no significant adverse changes in blood chemistry or organ weight up to dosages of 2000mg/kg bodyweight for 35 days, with exception to a decrease in testicle size possible due to a negative feedback response from androgenic activity. This dose is 320mg/kg bodyweight daily when converted to humans based on Body Surface Area.
Lower dosages (500mg/kg) have been tested for up to 13 weeks in rats of both genders with no side-effects noted.
A meta-analysis of 6 randomized trials noted that there were no reports of adverse effects associated with Ginger in the 6 studies selected as it pertains to pregnancy. Another review specifically investigated four trials and found no adverse effects at a dosage of 1g Ginger Extract.
Due to an anticoagulant effect of ginger, it should not be paired with pharmaceutical (prescription) drugs with the same effect such as Warfarin, and possibly NSAIDs such as Aspirin; doubly important when used during pregnancy.
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