Eucommia ulmoides

Eucommia ulmoides is a Traditional Chinese Medicine of which the bark is used for medicinal purposes. Although most evidence is preliminary, it has minor antiinflammatory properties may augment steroid signalling.

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Eucommia ulmoides is a Traditional Chinese Medicine that has been recommended for vitality enhancement and longevity. It is a collection of flavonoids (ones that are fairly common in the plant world) as well as both lignans and irioid compounds (both of which are not unique to this plant, but tend to be less common).

There is not a lot of human evidence on this plant at this moment in time except for one study noting reductions in blood pressure, but currently the animal evidence and mechanisms suggest that eucommia ulmoides could have a role in preventing bone loss, inducing fat loss, and reducing elevated blood pressure and triglycerides. At least one study suggests that the plant can augment steroid signalling without inherently being a strong agonist (applies to both androgens and estrogens), but this may apply to caprylic acid in general (which would then suggest that Coconut Oil is better at this role, due to providing much more caprylic acid).

It is not clear exactly how this plant burns fat or the molecules that mediate this effect, but currently the PPAR system is implicated and acute doses of the supplement have been confirmed to increase heat production in rats. The fat loss (or more acurately, anti-obese) effects of the plant in animal models is surprisingly potent among nutritional supplements.

This plant does have potential as a nutritional supplement as, unlike many other plants, it is active at relatively low oral dosages of 3,000mg or less (plant dry weight).

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Also Known As

Du Zhong, Gutta-Percha, Rubber Bark tree, Tochu


Do Not Confuse With

Euonymus alatus or Eurycoma Longifolia Jack (sound similar)


There is insufficient evidence to suggest an optimal dosage, but the limited human evidence and the animal evidence suggest a daily dose of around 3g of the leaf extract is effective for blood pressure and fat mass reduction. It may be prudent to use this in three daily doses of 1g, as the lone human study used thrice daily dosing.


Table of Contents:


Edit1. Sources and Composition

1.1. Sources

More commonly referred to as the Gutta-Percha or Rubber Bark tree or the Traditional Chinese Medicine known as Du Zhong, Eucommia ulmoides (of the Eucommiaceae family) is a medicinal plant where both the leaves and the bark have been used for the purposes of hastening relief of back pain, to increase stamina and recover from fatigue, and to make bones and muscles stronger[1] while promoting longevity and fertility.[2] When used in Kampo medicine, it goes by the name of Tochu[3] and the leaves are sometimes used to brew Tochu tea.

This plant also has some usage as a tree that can produce rubber[4] due to the trans-polyisoprene compounds it can produce,[5][6] which is why the tree also has the common name of 'Rubber Bark Tree'.

Eucommia ulmoides is a medicinal plant recommended to support vitality and strength, and also has commercial benefits as the tree can be used to manufacture rubber

1.2. Composition

The bark (ethanolic extract unless otherwise stated) has been noted to include:

  • Geniposidic acid (0.925% of bark) and its aglycone geniposide (0.488%) and genipin (0.214%)[7]
  • Trans-polyisoprene compounds, used mostly in rubber making[6]
  • Lignans (+)-pinoresinol-4,4′-di-O-β-D-glucopyranoside (pinoresinol diglucoside[8]), (+)-pinoresinol-4-O-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside, (+)-medioresinol-4,4′-di-O-β-D-glucopyranoside, (+)-syringaresinol-4,4′-di-O- β-D-glucopyranoside, (−)-olivil-4′-O-β-D-glucopyranoside, (−)-olivil-4-O-β-D- glucopyranoside, and (+)-pinoresinol-4-O-β-D-glucopyranoside[9] with both syringaresinol diglycoside (0.214%) and (+)-pinoresinol-di-β-d-glucopyranoside (0.991%) being quantified[7]
  • Licoagroside F (28.78+/-0.81μg/g)[10]
  • The flavonoids Baicalein (0.28+/-0.010μg/g), wogonin (0.20+/-0.0027μg/g), and oroxylin A (0.09+/-0.0040μg/g)[10]
  • Caprylic acid (involved in androgen signalling[1] and also found in Coconut Oil)
  • Triterpenoids[1]
  • Chlorogenic acid (0.302%)[7]

Whereas the leaves of Eucommia ulmoides include:

  • The irioid glycosides Geniposidic acid (10.1-17.4mg/g),[11][12] Aucubin (6.5-19.7mg/g; geniposidic acid without the carboxylic acid group),[12][13] and Asperuloside (13.7-27.8mg/g)[14][15]
  • Quercetin (0.27-0.62mg/g) as isoquercetin, rutin (7.6-14.3mg/g), and 3-O-sambubioside[11][12] as well as 3-O-alpha-L-arabinopyranosyl-(1->2)-beta-D-glucopyranoside[16]
  • Kaempferol and astragalin (kaempferol 3-O-beta-D-glucopyranoside)[16]
  • Licoagroside F at 8.97+/-0.41μg/g[10]
  • Baicalein (0.23+/-0.002μg/g), Wogonin (0.19+/-0.0030μg/g), and Oroxylin A (0.04+/-0.0004μg/g)[10]
  • Lignans Syringaresinol di-O-Glc (275.53+/-0.99μg/g) and Pinoresinol di-O-Glc (384.15+/-19.67μg/g)[10]
  • Chlorogenic Acid (26.3-46.9mg/g)[11][12][17]
  • Ferulic and caffeic acid[11]

The bark and leaves tend to possess both lignans and irioid glycosides as the active components, which are likely what set this plant out from others. The other phenolics in the plants are quite general to most plants and not in remarkable quantities in this plant

The water extract of the leaves is a relatively potent antioxidant with an IC50 of 18.9+/-0.2μg/mL in a DPPH assay (albeit weaker than the reference drugs of Vitamin C at 5.9+/-0.1μg/mL and Vitamin E at 9.7+/-0.2μg/mL)[11] The unique bioactive, geniposidic acid, does not appear to have significant antioxidant properties[11] and the total flavonoid content is 9.5-21.3mg/g of the leaves.[12]

There is a polysaccharide content of this plant (leaf or bark not specified) at around 23.6-24.1% of total weight[18] and the content of irioid glycosides appears to be less in this plant when directly compared to plantago asiatica (a plant related to Psyllium).[19] While the irioid glycosides can also be found in the seeds,[20] these parts of the plant are not commonly used as supplements nor functional foods.


Edit2. Pharmacology

2.1. Serum and Distribution

The irioid glycoside geniposide and its aglycone (genipin) have been detected in plasma and in organs (kidneys) following oral ingestion of the bark[7] and aucubin at 50mg/kg oral intake (rats) in isolation has been noted to peak in the blood at a Tmax of 1.08h and a Cmax of 4016+/-2394ng/mL and a fairly prolonged half-life of 7.38+/-2.9 hours.[21]

The lignan (+)-pinoresinol-di-β-D-glucopyranoside has been noted to be absorbed in rats with a Tmax of 1.56+/-0.87 hours and a half-life of 3.66 hours, being detected at a Cmax of 18.57+/-8.09ng/mL at an oral intake of 10mg/kg.[22]

Both the irioid glycosides as well as the lignans seem to have the potential to be absorbed, although pharmacokinetic data is somewhat limited as it is not sure what the active ingredient(s) is/are

2.2. Metabolism

Both irioid glycosides of genipin (geniposide and geniposidic acid) can be hydrolyzed into free genipin in intestinal bacteria.[23]

2.3. Mechanisms

Lignans in Eucommia ulmoides may have phosphodiestease (PDE) inhibiting properties, with IC50 values between 63.5-123.8µM and two (of seven tested) lignans having an IC50 greater than 200µM;[9] this has been noted previously against cAMP-related PDE enzymes[24] but an in-depth evaluation of which subsets of the PDE enzyme are inhibited and the selectivity of the lignans is not yet conducted.

May inhibit PDE enzymes, but due to the lack of research on selectivity and moderate potency (paired with unknown amounts of lignans in the plant) it is not sure how practically relevant this information is

The bioactive asperuloside has been found to inhibit PI3K with an IC50 of 2µM, being less potent than uttronin A (1.1µM) and hypericin (180nM)[25] while being more effective than emodin (3.3µM) and Quercetin.[26]

May inhibit PI3K


Edit3. Neurology

3.1. Mechanisms

Eucommia ulmoides stem bark extract appears to have acetylcholinesterase inhibiting properties in vitro (IC50 of 172μg/mL)[27] and is able to exert neuroprotective effects against beta-amyloid proteins (as assessed by memory formation and normalizing the increase in acetylcholinesterase)[27] and hydrogen peroxide with 5-20μg/mL preventing 30-70% of cytotoxicity, with 2.5μg/mL showing some efficacy in reducing oxidative biomarkers.[2] In isolation, both Chlorogenic Acid and geniposidic acid show protective effects.[28]

In rats given intracerebral injections of beta-amyloid proteins (induces Alzheimer's-like cognitive dysfunction), 5-20mg/kg of the stem bark extract noted that the higher range of intake (10-20mg/kg) protected from memory dysfunction.[27]

Appears to have neuroprotective properties, which have at least once been confirmed to occur in a living model at fairly reasonable oral dosages


Edit4. Cardiovascular Health

4.1. Blood Pressure

Mechanistically, eucommia ulmoides appears to possess beta-blocking potential as assessed by a lipolysis assay with isoproterenol.[29]

Eucommia ulmoides bark can also cause vasorelaxation in a concentration dependent manner in a way that is fully dependent on Nitric Oxide[30][31] and thought to be related to potassium channels.[31]

May have beta-blocking potential (thought to be related to the lignans) and may be vasorelaxant

Eucommia ulmoides appears to have antihypertensive effects due to its activating effects on the parasympathetic nervous system[32] and can work in a dose-dependent manner in spontaneously hypertensive rats.[33] In fructose overfed rats that develop insulin resistance and hypertension, 500-1000mg/kg of eucommia ulmoides can reduce blood pressure in a dose dependent manner but cannot completely normalize it.[34][35][36]

In prehypertensive humans, while supplementation of 500mg eucommia ulmoides (8% pinoresinol) daily for eight weeks only caused marginal reductions in blood pressure that faded with time a higher dose (1,000mg thrice daily) for two weeks has resulted in a reduction in both systolic and diastolic blood pressure by 7.5/3.9mmHg.[29]

Eucommia ulmoides appears to be reliably antihypertensive in rats, and a daily dose of 3g of the leaves has been shown at least once to be effective in humans


Edit5. Interactions with Glucose Metabolism

5.1. Mechanisms

Ingestion of eucommia ulmoides daily for 90 days in rats appears to reduce the expression of the GLUT4 transporter in rats given a high fat diet, yet increased expression in rats on a normal diet (not obesogenic) and increased expression in skeletal muscle.[15]

Appears to modify GLUT4 transporters in a somewhat unreliable manner

5.2. Insulin Sensitivity

In fructose drinking rats (a research model for fatty liver) given 500-1000mg/kg of eucommia ulmoides leaf extract over four weeks, the supplementation was able to fully normalize the changes in insulin and insulin sensitivity (HOMA-IR) without affecting blood glucose which was unaffected by fructose treatment initially.[34]

In streptozotocin-induced diabetic mice given eucommia ulmoides orally for four weeks (1,400mg/kg) was able to reduce blood glucose and normalize oxidative parameters such as SOD and MDA.[37]


Edit6. Fat Mass and Obesity

6.1. Mechanisms

Mechanistically, it has been noted that ingestion of Eucommia ulmoides is associated with increases in protein content of some intermediates of energy metabolism (isocitrate dehydrogenase 3, citrate synthase, pyruvate kinase, GLUT4, and H+ transporting mitochondrial F1 complex)[15] and in rat liver increases in the activity of genes involved in fat oxidation has been noted in the range of 1.21-1.88 fold (300-1,600mg/kg leaf extract intake)[38] which is thought to explain the increases in fat oxidation seen in the liver.[38][39][15] The increase was noted on the rate-limiting stages of β-oxidation (Cpt1a, Acox1, and Acadvl), α-Oxidation, and ω-oxidation (Cyp4a1).[38]

Differential effects have been noted on UCPs, with an increase in UCP3 seen in normal rats and an increase in UCP2 seen in high fat fed rats,[15] and PPARγ mRNA has been found to be increased.[15] The aforementioned genetic changes in liver enzymes also appear to be targets of PPARα and PPARδ, suggesting they may play a role.[38]

It is hypothesized that the above changes are due in part to geniposide and geniposidic acid as well as their aglycone (genipin) as they consist of most of the plant's phytochemicals by weight[38] and since geniposide has shown lipid reducing properties in isolation.[40]

Eucommia ulmoides appears to modify the levels of proteins involved in energy metabolism and expenditure and in particular the uncoupling proteins (mediates heat production and 'wastes' energy), but the exact mechanism of action underlying these observations is not yet clear

A study in anaethesized rats given an intraduodenal injection of eucommia ulmoides (1-5mg or 4-20mg/kg) noted an increase in sympathetic nerve activity in both white and brown adipose tissue, and in concious rats there was an increase in plasma fatty acids (154.5-156.6% at 1-5mg of the leaf extract) and body temperature.[41]

An increase in heat expenditure following a single dose has been noted in rats, following fairly reasonable oral dosages as well

At least one study, in assessing its mechanisms on blood pressure, has found beta-blocking properties in human fat cells able to reduce the effects of isoproterenol.[29] This suggests that eucommia ulmoides can suppress the effects of fat burners that signal via these receptors, namely Ephedrine or Synephrine.

It's beta-blocking potential, while beneficial to blood pressure, may antagonize the effects of other fat burner

6.2. Interventions

In mice given a high fat diet with 3% or 9% of either the leaf powder or water extract of eucommia ulmoides (corresponds to human doses of 0.99g and 2.35g respectively), the weight gain observed is abolished over 90 days of ingestion.[15] In normal mice on a normal diet, the addition of 9% eucommia ulmoides is associated with a nonsignificant trend to lose body weight (12%) and a significant reduction in triglycerides and NEFA with an increase in adiponectin,[15] and the high fat and normal diet groups given 9% were similar weights at the end of the trial.[15] The leaf powder and the water extract from the leaves are comparable in potency[15][42] and other studies tested have noted a failure for high doses (3-6g/kg) to affect body mass over 35 days in rats (despite a reduction in white adipose tissue mass)[43] and a failure for low doses (15.5mg daily) to reduce body mass in hamsters.[39] One study comparing 3% leaf extract against 10% found only the latter effective at reducing body weight,[41] although the degree of fat loss was less drastic and partially confounded with a reduction in food intake.[41]

In osteoporotic mice, 5% of the diet as the water extract of eucomia ulmoides leaves is able to attenuate the rate of fat gain.[44]

For rat studies that measure weight as a secondary data point, 500-1000mg/kg of the leaf extract over 4 weeks has failed to cause a significant fat reducing effect in fructose-overfed rats.[34]

Longterm ingestion of eucommia ulmoides in rats appears to cause minor fat loss and is more potently an anti-obese agent, there are a lack of human studies on this herb at this point in time


Edit7. Skeleton and Bone Mass

7.1. Mechanisms

It is possible that the antioxidant properties of Eucommia ulmoides leaf extract can preserve bone cell integrity in periods of oxidative stress, and is active in a concnetration dependent manner as low as 6.25µg/mL (EC50 being around 25µg/mL).[45] There has also been a noted inhibitory effect on osteoclastic formation attributed to the irioid glycosides.[46]

The enhancement of signalling via the estrogen receptor alpha[1] may also contribute to enhanced bone growth properties, but is unlikely to be the only mechanism at play (as there is still protection for bone in instances of estrogen deficiency such as rat ovarectomy[44][47]).

7.2. Osteoporosis

In ovarectomized rats, 5% of the diet as eucommia ulmoides appears to reduce the rate of bone loss in this menopausal research model[44] and the cortex in doses of 300-500mg/kg (but not 100mg/kg) appears to reduce the loss in bone mass over 16 weeks with a potency not significantly different than the reference drug estradiol.[47]


Edit8. Inflammation and Immunology

8.1. Mechanisms

Both genipin and geniposide have been noted to inhibit Nitric Oxide release from LPS-stimulated macrophages at a concentration of 12.5μM (7-10%), with genipin increasing in potency with near absolute suppression at 100μM[7] and both the cortex itself has shown similar properties (antiinflammatory properties against LPS-stimulated macrophages) between 0.05-0.5mg/mL to near half of control[48] and the bark has reported an IC50 against COX2 induction of 9.92μg/mL (meloxicam as reference drug was more potent at 0.18μM).[19]


Edit9. Interactions with Hormones

9.1. Testosterone

The androgen receptor is the receptor by which androgens (testosterone and DHT mostly, to a lesser degree DHEA) exert most of their biological effects.[49] Binding of a ligand (be it a hormone or plant) to the receptors is enough to induce effects,[50] and it appears that Eucommia ulmoides possesses phytoandrogens capable of this.[1]

In mammalian COS-7 cells, an ethanolic extract of the bark from Eucommia ulmoides is able to bind to and weakly activate the androgen receptor with enough affinity to displace testosterone with efficacy at a 5-25ng/mL range.[1] The addition of the extract to a medium containing DHT noted that even at saturating levels of DHT, Eucommia ulmoides augmented signalling in the range of 112-204% of baseline.[1] While this was found with the fractions containing triterpenoids, the caprylic acid content of Eucommia ulmoides and caprylic acid isolated from Coconut Oil both mimicked this augmentation.[1]

While oral intake of 1-50mg of the ethanolic extract in rats has failed to modify prostatic weights (suggesting weak androgenicity), it was able to increase the testosterone (5000mcg injection) induced prostatic growth by approximately 20%.[1]

Eucommia ulmoides appears to be androgenic, although weakly on its own. This plant appears to augment signalling of other androgens through the androgen receptor (thus increasing their efficacy) which is currently thought to be due to the caprylic acid content

9.2. Estrogen

Similar to the effects on the androgen receptor, Eucommia ulmoides (50ng/mL) strongly binds to and weakly activates the estrogen receptor (ERα) while augmenting the signalling of estradiol.[1]

Similar to its effects on the androgen receptor, this herb appears to augment signalling through the estrogen receptor (alpha confirmed, beta isoform not tested)

9.3. Cortisol

The augmenting effects of Eucommia ulmoides on the androgen and estrogen receptor do not appear to extend to the cortisol receptor nor the progesterone receptor.[1]

Does not appear to significantly modify signalling through the cortisol receptor

9.4. Growth Hormone

In isolated rat pituitary cells incubated with 20µg/mL of the n-hexane, chloroform, or ethyl acetate fractions, there appears to be a stimulation of growth hormone release.[46]

May stimulate growth hormone release, requires studies in living models to assess whether this is relevant or not


Edit10. Interactions with Organ Systems

10.1. Kidneys

The polysaccharides from this plant, at 300-600mg/kg for 15 days, appear to have protective effects in the kidneys as assessed by MDA and glutathione concentrations after renal ischemia reperfusion; this was attributed to antioxidant properties (Protective effects were confirmed by histological examination, and although 600mg/kg was close to normalization it was not fully protective)[18] and the overall bark extract (70% ethanolic) itself also has protective effects against cadmium at 125-500mg/kg.[7]

A mixture of panax pseuodoginseng and eucommia uloides (50% and 25% of weight respectively) at 10mg daily (35.7-41.6mg/kg) for six weeks after nephrectomy noted a mild protective effect on glomerular filtration rate and histological examination.[51]

References

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  2. Kwon SH, et al. Eucommia ulmoides Oliv. Bark. protects against hydrogen peroxide-induced neuronal cell death in SH-SY5Y cells. J Ethnopharmacol. (2012)
  3. Yang J, et al. Tochu (Eucommia ulmoides) leaf extract prevents ammonia and vitamin C deficiency induced gastric mucosal injury. Life Sci. (2003)
  4. Nakazawa Y, et al. Histochemical study of trans-polyisoprene accumulation by spectral confocal laser scanning microscopy and a specific dye showing fluorescence solvatochromism in the rubber-producing plant, Eucommia ulmoides Oliver. Planta. (2013)
  5. Bamba T, et al. Contribution of mevalonate and methylerythritol phosphate pathways to polyisoprenoid biosynthesis in the rubber-producing plant Eucommia ulmoides oliver. Z Naturforsch C. (2010)
  6. Chen R, et al. Overexpression of an isopentenyl diphosphate isomerase gene to enhance trans-polyisoprene production in Eucommia ulmoides Oliver. BMC Biotechnol. (2012)
  7. Liu E, et al. Eucommia ulmoides bark protects against renal injury in cadmium-challenged rats. J Med Food. (2012)
  8. Shi J, et al. Structure identification and fermentation characteristics of pinoresinol diglucoside produced by Phomopsis sp. isolated from Eucommia ulmoides Oliv. Appl Microbiol Biotechnol. (2012)
  9. Shi SY, et al. Combination of preparative HPLC and HSCCC methods to separate phosphodiesterase inhibitors from Eucommia ulmoides bark guided by ultrafiltration-based ligand screening. Anal Bioanal Chem. (2013)
  10. Chai X, et al. A rapid ultra performance liquid chromatography-tandem mass spectrometric method for the qualitative and quantitative analysis of ten compounds in Eucommia ulmodies Oliv. J Pharm Biomed Anal. (2012)
  11. Dai X, et al. Preparative isolation and purification of seven main antioxidants from Eucommia ulmoides Oliv. (Du-zhong) leaves using HSCCC guided by DPPH-HPLC experiment. Food Chem. (2013)
  12. Zhang Q, Su Y, Zhang J. Seasonal difference in antioxidant capacity and active compounds contents of Eucommia ulmoides oliver leaf. Molecules. (2013)
  13. Zheng J, et al. Enzymatic extraction and antibacterial activity of aucubin from Eucommia ulmoides leaves. Zhong Yao Cai. (2012)
  14. Studies on the chemical constituents of green leaves of Eucommia ulmoides Oliv
  15. Fujikawa T, et al. Chronic administration of Eucommia leaf stimulates metabolic function of rats across several organs. Br J Nutr. (2010)
  16. Kim HY, et al. Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory activity. J Ethnopharmacol. (2004)
  17. Li H, Chen B, Yao S. Application of ultrasonic technique for extracting chlorogenic acid from Eucommia ulmodies Oliv. (E. ulmodies). Ultrason Sonochem. (2005)
  18. Hong YK, et al. Optimization of extraction of Eucommia ulmoides polysaccharides by response surface methodology. Carbohydr Polym. (2013)
  19. Kim BH, Park KS, Chang IM. Elucidation of anti-inflammatory potencies of Eucommia ulmoides bark and Plantago asiatica seeds. J Med Food. (2009)
  20. Li H, et al. Extraction of aucubin from seeds of Eucommia ulmoides Oliv. using supercritical carbon dioxide. J AOAC Int. (2009)
  21. Xu W, et al. A rapid and sensitive determination of aucubin in rat plasma by liquid chromatography-tandem mass spectrometry and its pharmacokinetic application. Biomed Chromatogr. (2012)
  22. Wang JL, et al. Validation of a HPLC-tandem MS/MS method for pharmacokinetics study of (+)-pinoresinol-di-β-D-glucopyranoside from Eucommia ulmoides Oliv extract in rats' plasma. J Ethnopharmacol. (2012)
  23. Akao T, Kobashi K, Aburada M. Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Biol Pharm Bull. (1994)
  24. Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Lignan Glucosides of Eucommia Bark
  25. Frew T, et al. A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors. Anticancer Res. (1994)
  26. Matter WF, Brown RF, Vlahos CJ. The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs. Biochem Biophys Res Commun. (1992)
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  28. Zhou Y, et al. Protective effects of Eucommia ulmoides Oliv. bark and leaf on amyloid β-induced cytotoxicity. Environ Toxicol Pharmacol. (2009)
  29. Greenway F, et al. A clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertension. Altern Med Rev. (2011)
  30. Kwan CY, et al. Endothelium-dependent vascular relaxation induced by Eucommia ulmoides Oliv. bark extract is mediated by NO and EDHF in small vessels. Naunyn Schmiedebergs Arch Pharmacol. (2004)
  31. Kwan CY, et al. Endothelium-dependent vasorelaxant effects of the aqueous extracts of the Eucommia ulmoides Oliv. leaf and bark: implications on their antihypertensive action. Vascul Pharmacol. (2003)
  32. Constituents and pharmacological effects of Eucommia and Siberian Ginseng
  33. Effect of Eucommia Leaf (Eucommia ulmoides Oliver; Du-Zhong yge) Extract on Blood Pressure
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  37. He K, et al. Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice. J Ethnopharmacol. (2011)
  38. Kobayashi Y, et al. Facilitative effects of Eucommia ulmoides on fatty acid oxidation in hypertriglyceridaemic rats. J Sci Food Agric. (2012)
  39. Choi MS, et al. Du-zhong (Eucommia ulmoides Oliver) leaf extract mediates hypolipidemic action in hamsters fed a high-fat diet. Am J Chin Med. (2008)
  40. Wu SY, et al. Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Acta Pharmacol Sin. (2009)
  41. Horii Y, et al. Effects of Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food intake, and body weight. Neurosci Lett. (2010)
  42. Hirata T, et al. Anti-obesity compounds in green leaves of Eucommia ulmoides. Bioorg Med Chem Lett. (2011)
  43. Metori K, et al. Effects of du-zhong leaf extract on serum and hepatic lipids in rats fed a high-fat diet. Biol Pharm Bull. (1994)
  44. Zhang W, et al. Eucommia leaf extract (ELE) prevents OVX-induced osteoporosis and obesity in rats. Am J Chin Med. (2012)
  45. Lin J, et al. Eucommia ulmoides Oliv. antagonizes H2O2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3, 6, 7, and 9. J Zhejiang Univ Sci B. (2011)
  46. Ha H, et al. Effects of Eucommiae Cortex on osteoblast-like cell proliferation and osteoclast inhibition. Arch Pharm Res. (2003)
  47. Zhang R, et al. Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats. Bone. (2009)
  48. Kim MC, et al. Eucommiae cortex inhibits TNF-α and IL-6 through the suppression of caspase-1 in lipopolysaccharide-stimulated mouse peritoneal macrophages. Am J Chin Med. (2012)
  49. Davison SL, Bell R. Androgen physiology. Semin Reprod Med. (2006)
  50. Schaufele F, et al. The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions. Proc Natl Acad Sci U S A. (2005)
  51. Harada M, et al. Beneficial modification of functional renal parameters in 5/6 nephrectomized rats by nutraceutical. In view of a kidney-protective intervention. Acta Biomed. (2011)

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