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Citric acid is a compound that, in the body, is created for production of cellular energy via the TCA cycle. Supplementation with it has not been shown to increase energy levels as enough is made by the body.
It has an alkalinizing effect on the body when ingested and has been shown in a limited amount of studies to exert some protection against calcium loss in post-menopausal osteroporetic women.
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Citric Acid is non-stimulatory.
Alkalinizing effects of Citric acid supplementation have been shown in high doses of 0.1g/kg bodyweight, which is 8.2g a day for a 180lb person.
Much ado about nothing
Citric acid is an intermediate in the Citric Acid Cycle (TCA, or Kreb's Cycle) in the mitochondria and is synthesized in the first step via the combination of oxaloacetate and Acetyl-Coa via Citrate Synthase (to produce Citrate). It is the first step of the TCA cycle, but not the rate limiting step (which is the decarboxylation step of isocitrate dehydrogenase, or step 5).
Citric acid is commonly supplemented as an aims to reduce body acidity, it has once been hypothesized that an acidic diet leeches alkaline minerals from bone to counteract changes in body acidity, thus reducing bone mass (as most minerals deposited in bone are alkaline in nature).
In regards to bone metabolism, one study found that low (0.72g) and high (2.16g) dose potassium citrate supplementation has not been shown to have a significant effect on reducing the effects of osteoporosis and the loss of bone turnover in and of itself although it seems to be able to ameliorate calcium losses induced by a high sodium intake. Another short-term study, using much higher doses (0.1g/kg bodyweight) found beneficial effects on bone metabolism as judged by urinary excretion.
(Common misspellings for Citric Acid include citic, citrc, citrik, acd, asid)
(Common phrases used by users for this page include tca cycle supplement, take citric acid supplements for energy, is citric acid bad for bones\, information about krebs cycle, citric acid maximum daily dose, citrate sythase supplement)