All Essential Benefits/Effects/Facts & Information
This page on Centrophenoxine is currently marked as in-progress. We are still compiling research.
Centrophenoxine is a Cholinergic compound with a DMAE (Dimethylaminoethanol) component, and acts as a better absorbed transporter of DMAE into the brain. It is sold under the brand name Lucidril but can easily be bought over the counter or online.
It is effective in reversing some of the signs of aging (particularly waste product buildup in the brain) when taken for an acute period (high doses for a month) and can act as a general neural enhancer and protector when taken continuously at a lower dose.
Also Known As
Centro, Lucidril (Brand Name)
Things to Note
Centrophenoxine, via increasing acetylcholine levels, is stimulatory.
Is a Form Of
Goes Well With
Centrophenoxine, via its DMAE subset, may also exert teratogenic (birth-defects) effects. Due to this Centrophenoxine should not be used by females of child-bearing age.
Examine.com Medical Disclaimer
How to Take
Recommended dosage, active amounts, other details
For therapeutic usage in reducing lipofuscin (for the aged) 3-6 doses of 250mg centrophenoxine is generally touted.
For younger individuals seeking neurological enhancement and neuronal protection, 1-3 doses of 250mg suffices.
Editors' Thoughts on Centrophenoxine
(Would be good to read the DMAE article in addition to this one)
Centrophenoxine looks promising for a 1-time cognition boost. Unlike many supplements, one 'cycle' of Centrophenoxine could yield benefits for much longer than just the time ingested. Unlike other compounds where one would need to take it everyday for life, one can take a bottle of Centrophenoxine and reap benefits for a long time.
A good consideration for those wary of supplementation and the commitment it entails.
Table of Contents:
Effects in the Brain
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Centrophenoxine is able to reverse lipofuscin/beta-amyloid pigmentation build-up as well as act as an anti-oxidant against lipid peroxidation. Centrophenoxine can also increase RNA synthesis, protein synthesis, and glucose uptake in neurons and glial (support) cells. These latter effects are, however, dependent on the reductions of lipofuscin build-up and don't appear to affect youth with no lipofuscin build-up.
Centrophenoxine has been shown to be efficacious in treating dementia by increasing intracellular water content (of which dehydration is consistent with aging) and by increasing skills on cognition testing after 8 weeks of a 2g dose.
Centrophenoxine, via its DMAE moiety, may act as a teratogen in the same manner as DMAE which can be reviewed under DMAE's Teratogenic Summary
Scientific Support & Reference Citations
Sharma D, Maurya AK, Singh R Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine
. Neurobiol Aging. (1993)
Ludwig-Festl M, Gräter B, Bayreuther K Increase in cell metabolism in normal, diploid human glial cells in stationary cell cultures induced by meclofenoxate
. Arzneimittelforschung. (1983)
Watanabe S, et al Effects of various cerebral metabolic activators on glucose metabolism of brain
. Folia Psychiatr Neurol Jpn. (1975)
Fülöp T Jr, et al Effects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trial
. Arch Gerontol Geriatr. (1990)
Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, et al Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial
. JAMA. (2015)
Taylor MJ1, et al Folate for depressive disorders
. Cochrane Database Syst Rev. (2003)
Godfrey PS1, et al Enhancement of recovery from psychiatric illness by methylfolate
. Lancet. (1990)
Kushwaha S1, Chawla P1, Kochhar A1 Effect of supplementation of drumstick (Moringa oleifera) and amaranth (Amaranthus tricolor) leaves powder on antioxidant profile and oxidative status among postmenopausal women
. J Food Sci Technol. (2014)
(Common misspellings for Centrophenoxine include centrophenoxin, centrophinoxine, centrophinoxine, sentrophenoxine, sentrophenoxin)
(Editors who contributed to this page include
KurtisFrank, Sol )