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Capsicum Carotenoids are two pigments from the Capsicum family of vegetables (most well known for peppers and cayenne, and to a lesser degree paprika). These pigmentations belong to the class of carotenoids, and are reddish in nature.
They affect metabolism of other compounds and pharmaceuticals by acting as inhibitors of a class of proteins that eject some drugs and supplements from inside cells, and can also eject supplements from the liver back into the intestine. For supplements that are subject to these protein transports, inhibiting the transports increases the amount of supplement taken up by the body.
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Capsicum Carotenoids include the two structurally similar compounds Capsorubin and Capsanthin.
They are found in all capsicum vegetables and fruits, and are found in very high amounts in both deep red chillies, cayenne, and paprika; the latter ranging from 3-8g/kg total carotenoids. Specifically, the capsicum carotenoid content of cayenne is approximately 2.01 capsanthin and 0.31 capsorubin, and paprika has values of 2.19-3.49 capsanthin and 0.42 to 0.98 capsorubin (all numbers g/kg)
2Reversal of Multidrug Resistance
Multidrug Resistance proteins (MDRs) are protein transports on tumor cells and other cells such as intestinal cells. They serve to eject compounds that build up in a cell, and exist as a defense mechanism for said cell.
Both Capsorubin and Capsanthin are able to potently inhibit P-Glycoprotein and MDR-1, two well-characterized efflux proteins. Via this action they may increase the bioavailability of some compounds, such as Berberine.
Scientific Support & Reference Citations
COLOR EVALUATION OF SELECTED CAPSICUMS
A qualitative study of the carotenoid pigments of Sri Lanka chillies (Capsicum annum)
Quantitative changes in carotenoids during the storage of dried red pepper and red pepper powder
Molnár J, et al Inhibition of multidrug resistance of cancer cells by natural diterpenes, triterpenes and carotenoids
. Curr Pharm Des. (2006)
Molnár J, et al Reversal of multidrug resitance by natural substances from plants
. Curr Top Med Chem. (2010)
Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, et al Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial
. JAMA. (2015)
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. Cochrane Database Syst Rev. (2003)
Godfrey PS1, et al Enhancement of recovery from psychiatric illness by methylfolate
. Lancet. (1990)
Kushwaha S1, Chawla P1, Kochhar A1 Effect of supplementation of drumstick (Moringa oleifera) and amaranth (Amaranthus tricolor) leaves powder on antioxidant profile and oxidative status among postmenopausal women
. J Food Sci Technol. (2014)
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