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Capsicum Carotenoids are two pigments from the Capsicum family of vegetables (most well known for peppers and cayenne, and to a lesser degree paprika). These pigmentations belong to the class of carotenoids, and are reddish in nature.
They affect metabolism of other compounds and pharmaceuticals by acting as inhibitors of a class of proteins that eject some drugs and supplements from inside cells, and can also eject supplements from the liver back into the intestine. For supplements that are subject to these protein transports, inhibiting the transports increases the amount of supplement taken up by the body.
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Capsicum Carotenoids include the two structurally similar compounds Capsorubin and Capsanthin.
They are found in all capsicum vegetables and fruits, and are found in very high amounts in both deep red chillies, cayenne, and paprika; the latter ranging from 3-8g/kg total carotenoids. Specifically, the capsicum carotenoid content of cayenne is approximately 2.01 capsanthin and 0.31 capsorubin, and paprika has values of 2.19-3.49 capsanthin and 0.42 to 0.98 capsorubin (all numbers g/kg)
Multidrug Resistance proteins (MDRs) are protein transports on tumor cells and other cells such as intestinal cells. They serve to eject compounds that build up in a cell, and exist as a defense mechanism for said cell.
Both Capsorubin and Capsanthin are able to potently inhibit P-Glycoprotein and MDR-1, two well-characterized efflux proteins. Via this action they may increase the bioavailability of some compounds, such as Berberine.
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