Anacyclus Pyrethrum (Akarhara) is a traditionally used aphrodisiac in Ayurveda; it is currently being investigated as a Testosterone Booster in mice and appears to be effective at Testosterone boosting and aphrodisia; human studies are lacking.
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Anacyclus Pyrethrum is a herbal aphrodisiac from Ayurvedic medicine, in which a mixture of its roots is sometimes referred to as Akarhara. It is currently being investigated for its benefits on male fertility and testosterone levels.
It is currently in the preliminary stages of research, but appears to exert pro-aphrodisiac effects and increase testosterone in animal models that are otherwise normal functioning and healthy.
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Akarkara, Vajikaran Rasayana, Pellitory Root, Spanish Chamomile
Studies in rats use a range of 50-150mg/kg bodyweight Anacyclus Pyrethrum roots (DC) daily. Using rat to human conversions on Body Surface Area[1] this results in a daily dose of 8-24mg/kg bodyweight, or a range of 727-2,181mg daily for a 200lb male.
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Anacyclus Pyrethrum is a plant and Ayurvetic herb sometimes referred to as 'Vajikaran Rasayana' or 'Akarhara'. Specifically, Akarhara is the dried roots of Anacyclus Pyrethrum.[2] It has been used traditionally as an aphrodisiac and male fertility herb, which are also the uses which are most heavily touted. Other usages for Akarhara traditionally include its usage as a 'brain tonic' and it is sometimes used to treat paralysis and hemiplegia, cephalalgia (headache), epilepsy and rheumatism.[3]
Related to its usage as a 'brain tonic' and treatment of headaches is the belief that it can increase blood flow to the head and face and 'purge' the body of toxins through stimulating mucus production. Basically, Anacyclus has been used orally to increase salivation and nasal mucus flow.[4]
Its interactions with the immune system suggest it may serve some function as an Adaptogen.[5]
As a herbal supplement, Anacyclus Pyrethrum contains a variety of compounds including:
A study investigating oral doses of Anacyclus root noted increases in testosterone with all dosages in a dose-dependent manner, with the 150mg/kg bodyweight group having serum testosterone levels of 4.22 ± 0.13 ng/mL; control was just below 2ng/mL, 50mg/kg bodyweight Anacyclus just above 2ng/mL and 100mg/kg just surpassing 3ng/mL with all supplemental groups statistically greater than control.[2] As an active control, 0.5mg/kg bodyweight testosterone injections twice weekly resulted in serum levels of testosterone just below 3ng/mL.[2]
Follicle-Stimulating Hormone and Lutenizing Hormone show similar dose dependent increases with Anacyclus supplementation despite testosterone injections suppressing levels.[2]
The effects seen on testosterone are hypothesized to be from akylamide compounds stimulating the hypothalamus, as previous studies on N-akylamide structures note androgenic activities.[7]
One study investigating 50,100 and 150mg/kg Anacyclus.P over 28 days in rats noted dose-dependent increases in the weight of male sexual organs (testes, epididymus, seminal vesicles and prostate)[2] with the overall effects of 150mg/kg bodyweight similar to that of 0.5mg/kg bodyweight intramuscular testosterone twice weekly. This comparison has been made in another study which found similar results, although the effects of Anacyclus appear to last longer than that of injectible testosterone after cessation of treatment.[8]
These dosages were also effective in increasing the seminal parameters of motility, viability, and sperm count; this is in accordance with Anacyclus.P's usage as a pro-fertility agent.[2] These effects have been seen by other researchers at dosages of 50 and 100mg/kg bodyweight as well as an aphrodisiac effect in male rats.[9][8]
Both studies in rats that investigate structural changes of rat sexual organs after supplementation note that changes seen rival that of testosterone.[9][2]
Good preliminary evidence for test boosting in otherwise healthy rats, but further study is needed on mechanisms and humans.
Higher dosages of Anacyclus appear to be effective in reducing the damage induced by seizures, such as oxidation and cognitive decline, in a relatively dose-dependent manner.[3] Alterations in cholinergic transmission, thought to precede memory loss following seizures, was prevented with Anacyclus pretreatment.[3]
Anacyclus Pyrethrum has been suggested to stimulate the immune system;[4] this is through increasing the phagocytic activity of the reticulo-endothelial system (RES) for doses up to 50mg/kg bodyweight in rats, with the effects being eliminated at 100mg/kg bodyweight.[4] An increase of macrophage count as well enhanced lymphocyte proliferation were also observed in the spleen of treated rats, with an effect seen at 50mg/kg but not at 100mg/kg.[4]
An oral dose of Anacyclus (petroleum ether extract) has been shown to resist the suppression of the immune system induced by the immune suppressant cyclophosphamide, whereas both groups (50mg/kg and 100mg/kg in rats) had (slightly) better immune function than controls despite cyclophophamide insult, and without the insult had significantly better immune function.[5]
The only current safety information on Anacyclus Pyrethrum was a study done on rats in which the selected dosages for the study (50 and 100mg/kg bodyweight) were decided due to being 1/20th and 1/10th of the LD50 of the compound; this establishes the LD50 as found by these researchers at 500mg/kg bodyweight in rats.[5]
These numbers, after conversion to humans based on Body Surface Area, would be 80mg/kg bodyweight or 7.3g Anacyclus Pyrethrum DC (root extract) for a 200lb man.
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