7-Keto DHEA

7-Keto DHEA is a metabolite of Serum DHEA that is nonhormonal, and it appears to be a fat loss agent as it may increase the metabolic rate. Studies in humans show promise for helping during a fat loss diet, but currently are of questionable quality due to potential conflicts of interest.

This page features 48 unique references to scientific papers.

Summary

All Essential Benefits/Effects/Facts & Information

7-oxodehydroepiandrosterone (7-oxo DHEA and more commonly known as the brand name 7-keto) is one of three oxygenated metabolites of Dehydroepiandrosterone, and these three oxygenated metabolites interconvert with one another but do not convert back into parent DHEA; 7-keto supplementation is a way to get these three oxygenated metabolites without using DHEA supplementation, and DHEA may form androgenic and estrogenic hormones via an alternate metabolic pathway (which 7-keto does not participate in).

7-keto supplementation is mostly known to not be hormonal; it can interact with steroid metabolism but the exact manner in which it does it not fully elucidated. It does appear to have anti-cortisol mechanisms as the enzymes that activate cortisol (from the relatively inactive precursors of cortisone and corticosterone) are the same that interconvert these oxygenated metabolites. Although it appears to be anti-cortisol by its mechanisms, there is insufficient evidence to support these mechanisms in the body following oral supplementation.

Studies using 7-keto supplementation tend to note an increased metabolic rate later on during a caloric restriction period (which is secondary to reducing the rate of metabolic rate decline associated with dieting, and becoming a relative increase) although the quantity of data on this is pretty minimal if we exclude studies with possible conflicts of interest or those that use 7-keto alongside a multitude of supplements.

7-keto appears to be a somewhat promising non-hormonal fat burning agent but requires more evidence on both of those claims.

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Things To Know

Also Known As

7-ketodehydroepiandrosterone, 7-oxodehydroepiandrosterone, 7-ketoDHEA, 7-oxoDHEA, 7-oxo, 7-keto

Do Not Confuse With

Dehydroepiandrosterone (parent molecule)

Things to Note

  • For the most part, 7-keto supplementation is neither estrogenic nor androgenic

Is a Form Of

Caution Notice

Examine.com Medical Disclaimer

How to Take

Recommended dosage, active amounts, other details

A typical supplemental dosage of 7-keto is 200-400mg daily in two divided doses (100-200mg), some limited evidence suggests that lower doses of 50-100mg may be effective for neural purposes.

The optimal dosing schedule and overall dose of 7-keto is not yet known, and the above dosages are just based on what is known to have efficacy.

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects 7-keto dhea has on your body, and how strong these effects are.

Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
Metabolic Rate Notable Very High See study
Somewhat notable as the decrease seen with dieting was effectively abolished and reversed with 7-keto supplementation over 7 days of low caloric intake, but more evidence is required to establish the reliability of this and how strong it actually is.
Fat Mass Minor Very High See study
The amount of fat lost appears to be more with 7-keto than with placebo when either of them are paired with a low calories weight loss regiment.
Serum T3 Minor Very High See study
There appears to be an increase in circulating T3 hormone levels (active thyroid hormone) when 7-keto is paired with a caloric restriction and exercise (relative to placebo with the same regimen)
Weight Minor Very High See study
A weight loss of 2.88kg (1.8% body fat) was seen with 7-keto over placebo (0.97 kg loss with 0.28% bodyfat) which is significant but not overly notable, since the study used obese persons and exercise
Blood Glucose - Very High See study
Insufficient evidence to support changes in blood glucose
Blood Pressure - Very High See study
Insufficient evidence to support changes in blood pressure following 7-keto supplementation.
Estrogen - Very High See study
Insufficient evidence to claim changes in estrogen following 7-keto supplementation.
Fatigue - Very High See study
Insufficient evidence to support changes in fatigue and energy following 7-keto supplementation.
Parathyroid Hormone - Very High See study
Insufficient evidence to support changes in parathyroid hormone from 7-keto supplementation.
Serum T4 - Very High See study
Insufficient evidence to support alterations in T4, with no changes detected when it is measured
Testosterone - Very High See study
Insufficient evidence to support changes in testosterone following 7-keto supplementation.

Studies Excluded from Consideration

  • Confounded with the inclusion of other nutrients[1][2]


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Scientific Research

Table of Contents:

  1. 1 Sources and Structure
    1. 1.1 Sources
    2. 1.2 Structure and Properties
  2. 2 Pharmacology
    1. 2.1 Serum
    2. 2.2 Metabolism
    3. 2.3 Topical Application
  3. 3 Neurology
    1. 3.1 Memory and Cognition
    2. 3.2 Fatigue
    3. 3.3 PMS
    4. 3.4 Alcoholism
    5. 3.5 Stress
  4. 4 Cardiovascular Health
    1. 4.1 Blood Pressure
  5. 5 Fat Mass and Obesity
    1. 5.1 Mechanisms
    2. 5.2 Interventions
  6. 6 Interactions with Aesthetics
    1. 6.1 Hair
    2. 6.2 Skin
  7. 7 Interactions with Hormones
    1. 7.1 Cortisol
    2. 7.2 Androgens
    3. 7.3 Estrogen
    4. 7.4 DHEA and related molecules
    5. 7.5 Sex Hormone Binding Globulin
    6. 7.6 Thyroid Hormones
    7. 7.7 Gonadotropins
  8. 8 Safety and Toxicology

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1Sources and Structure

1.1. Sources

7-Keto DHEA (henceforth 7-keto) is a molecule derived from Serum DHEA (3β-Hydroxy-5-Androstene-17-one). 7-keto is synonymous with 7-oxo or 7-oxo DHEA as the ketone group added contains any oxygen molecule; 7-keto is more commonly used but is a brand name, while 7-oxo is the technically accurate name.[3] 7-keto is naturally occurring (as DHEA is naturally occurring and the enzymes that mediate the conversion present in the human body) at a highly variable level of 0.280+/-0.227nmol/L in serum with undetectable levels in some persons,[4] with this one study failing to note any differences between gender or age after 25[4] (DHEA itself is known to decline with age).

Supplementation of 7-keto is sometimes used with the acetyl ester, known fully as 3β-Acetyl-7-ketoDHEA.[5] Supplementation of 7-keto is sometimes used in place of supplementation of DHEA if the androgenic and estrogenic effects of DHEA are not desired, as 7-keto is incapable of converting to these active steroid hormones.

An endogenously produced metabolite of DHEA that appears to be more involved with corticosterone metabolism and is not inhernetly a steroid precursor like DHEA is

1.2. Structure and Properties

7-oxygenated metabolites appeared to be prone to dehydration ex vivo.[6]


2Pharmacology

2.1. Serum

The acetylated form of 7-keto (3β-acetyl-7-oxo-DHEA) appears to be rapidly metabolized to a sulfated form of 7-keto (7-ketoDHEA 3βsulfate[7]) with free 7-ketoDHEA as an intermediate, as the acetate group and the sulfate group occur on the same carbon.[5] Sulfation or acetylation of 7-keto at the 3-position does not appear to interfere with the induction of fat burning enzymes (mentioned in section on fat mass and obesity).[8]

7-ketoDHEA, similar to DHEA, can exist in a free form or a sulfated form in the body

2.2. Metabolism

7-keto DHEA is one of many metabolites of Dehydroepiandrosterone (DHEA),[9] where DHEA is converted into 7α-hydroxyDHEA (Oxysterol 7α-hydroxylase,[10] CYP3A4/5,[11] or CYP7B1[10][12]) and then can be converted into 7β-hydroxyDHEA via 11β-HSD type 1[13][14] and this conversion can occurs in a wide variety of tissues including the brain, spleen, thymus, perianal skin, ventral skin, intestine, colon, coecum and skeletal muscle.[15][16][17] 11β-HSD type 1 can then convert either 7α or 7β hydroxyDHEA into 7-oxo-DHEA (synonymous with 7-keto).[18][19] Due to the irreversibility of the Oxysterol 7α-hydroxylase and CYP3A4/5 enzymes, there is no conversion of these three molecules back into parent DHEA, and the metabolism of DHEA into androgenic or estrogenic precursors (into androstenedione via 3β-HSD) cannot occur following 7-keto supplementation.[17]

The activity of 11β-HSD1 balances the oxygenated DHEA metabolites between one another[20] and the enzyme known as Hexose-6-phosphate dehydrogenase appears to influence favorably conversion of these oxygenated metabolites into 7β hydroxyDHEA.[21]

7-keto is one of three 'oxygenated DHEA metabolites', and cannot be converted into DHEA after supplementation due to the conversion of DHEA into these oxygenated metabolites occurring in only one direction rather than a multidirectional function (A -> B only, rather than A being interchangeable with B)

2.3. Topical Application

7-keto appears to be biologically active when administered as a topical cream at the dosage of 25mg.[22]


3Neurology

3.1. Memory and Cognition

Injections of either DHEA (20mg/kg) or 7-keto (24mg/kg) in mice who were also injected with the learning neurotoxin scopolamine noted that both treatments noted that both neurosteroids were able to abolish the learning impairment induced by scopolamine in young mice, and that young mice given either neurohormone without scopolamine appeared to outperform control mice in memory acquisition training but this trend was not statistically significant.[23] In older mice given 7-keto without scopolamine, there were improvements in memory retention that were not seen with parent DHEA[23] (benefit has been noted with DHEA when injected directly into the brains of older mice[24][25][26])

Preliminary evidence that 7-keto can reduce memory impairment by cholinergic toxins or by age, but the studies are currently using injections with no human evidence

3.2. Fatigue

One study using 200mg 7-keto for 8 weeks in combination with a calorically restricted diet and exercise program (both adminstered to placebo) failed to find any significant difference in post-intervention ratings of fatigue or vigor (assessed via Profile of Mood States).[27]

Currently no evidence to support a reduction in fatigue associated with 7-keto supplementation

3.3. PMS

When assessing neurohormones of women during the midfollicular and midluteal phases of their menstrual cycles, it was noted that despite no changes in parent DHEA that there was a lower circulating level of oxygenated metabolites including 7-keto; the authors hypothesized that oxygenated DHEA metabolites may play a role in mood changes associated with menopause.[28]

Endogenous 7-keto and the oxygenated DHEA metabolite appear to be reduced in the brain during a menstrual cycle, and are thought to be related to mood changes (as they are neurohormones). There are currently no studies using supplementation to assess this claim

3.4. Alcoholism

In rats conditioned to respond to Alcohol ingestion (operant conditioning), acute consumption of 7-keto (10-56mg/kg) was able to reduce responding to alcohol, suggesting of possible anti-alcoholic effects; these effects were also noted with DHEA (10-180mg/kg).[29] 7-keto DHEA and DHEA itself were equally efficacious in reducing blood alcohol (in a dose dependent manner) while 7-keto was more effective at reducing response to a near absolute degree at 56mg/kg;[29] the authors noted that this may not have been an inherent effect (as DHEA is known to not alter alcohol metabolism[30]) and is likely indicative of less alcohol consumption in the rats.[29]

7-keto appears to have a fair bit of animal evidence to support its usage as an anti-alcohol consumption agent, and has more potency than parent DHEA. Fairly potent in animal studies and awaiting human trials

3.5. Stress

One letter to the editor[31] notes 5 case reports where severe trauma (stemming from childhood abuse) noted that in these treatment resistant women supplementation of 7-keto was associated with rapid improvements in vocational and interpersonal functioning and subjective improvements after 25-50mg for 4-6 weeks (in one case a dose of 75mg was used).[31]

A few case studies reporting that 7-keto can improve stress in trauma patients, no trails conducted


4Cardiovascular Health

4.1. Blood Pressure

Despite being associated with greater weight loss than placebo, one study using 200mg 7-Keto for 8 weeks in obese persons failed to find any significant influence on systolic or diastolic blood pressure at rest.[27]

Not enough evidence to assess the interaction of 7-keto DHEA and blood pressure


5Fat Mass and Obesity

5.1. Mechanisms

Higher (non-supplemental) circulating levels of Oxygenated derivatives of DHEA have been correlated with less obesity in vivo in males but not females, and is thought to be associated with the state of less body fat.[32]

In regards to activation of 'thermogenic enzymes' (mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, their induction decreasing efficiency of the TCA cycle and acts as an uncoupling agent[8][33][34]) 7-keto as well as the similar structures 7α-hydroxyDHEA and 7β-hydroxyDHEA are all active, although 7-keto moreso; DHEA per se is ineffective.[8] Induction of these enzymes appears to reduce mitochondrial membrane potential and increase substrate oxidation rates, which appears to be similar to thyroid hormones in action.[35]

One study feeding rats 7-keto at 0.2% of feed for 6-9 days noted that the rates for liver mitochondrial enzymes were increased for sn-glycerol-3-phosphate dehydrogenase (569%) and the protein content increased for malic enzyme (859%), sn-glycerol-3-phosphate dehydrogenase (137%), fatty acid acetyl-CoA oxidase (128%), and catalase (66.8%).[35]

7-keto appears to induce enzymes associated with mitochondrial membrane permeability, increasing permeability and secondary to that exerting an uncoupling effect where more substrate must be oxidized to meet cellular ATP quota

5.2. Interventions

One study using 7-Keto in isolation at 200mg (100mg twice a day for 7 days) noted that, during a period of caloric restriction (800kcal less than regular intake), metabolic rate increased an average of 1.4% (total caloric expenditure a highly variable 21+/-115kcal) while placebo experienced a decrease in metabolic rate by 3.9% relative to baseline; this study was too short in duration to assess changes in weight.[36]

In accessing the metabolic rate, 7-Keto supplementation appears to attenuate or reverse the decline in metabolic rate associated with caloric restriction

Studies conducted over a longer period of time note that 200mg (100mg twice daily) for 8 weeks in obese adults in combination with a weight loss diet (1800kcal mixed diet) and exercise program (3 days weeks cross training) noted that the loss in weight associated with placebo (0.97kg) was increased (2.88kg) as well as the fat loss (from 0.57% to 1.8%); no significant differences in dietary intake were reported.[27]

Studies measuring weight loss associated with 7-keto note that supplementation results in more weight and fat loss over a period of time; both studies were paired with diet and exercise which may be prerequisites

Another trial (external funding source and confounded with Asparagus racemosus, Choline, Inositol, L-Tyrosine and minerals) noted that pairing 400mg 7-Keto (200mg twice daily) with a calorically restricted diet (25kcal/kg of target body weight) and exercise program for 8 weeks noted similar effects (increasing weight loss from 0.72+/-2.12kg in placebo to 2.15+/-2.38kg; high variability seemed to be due to exercise/diet intervention rather than supplementation as it occurred in placebo).[1]

One study using 7-keto at 200mg (alongside Green Tea Catechins, chromium, Vitamin D, Vitamin C and calcium) during a period of caloric restriction in obese adults noted that the supplement was associated with a 3.4% increase in metabolic rate (59+/-118kcal) while placebo decreased 3.4%.[36] One study suggests a spike n 7.2% of the metabolic rate, but this study used a subactive dose of 7-Keto (17mg) paired with a variety of stimulatory compounds (Yerba mate at 167mg, piper nigrum at 1.7mg, 50mg Coleus forskohlii, 100mg Citris Aurantium at 6% Synephrine, and 233mg Guarana at 22% Caffeine).[2]

Some studies suggest higher spikes in metabolic rate but are confounded with inclusion of other nutrients and not very respective of the bioactivity of 7-keto in isolation


6Interactions with Aesthetics

6.1. Hair

Hair follicle related cells have been noted to possess CYP7B1, although 11β-HSD1 was not detected.[12]

6.2. Skin

The CYP7B1 enzyme has been detected in keratinocytes and both the spinous and granula layers, with some in the basal layer and basal cell bodies but minimal in the dermis;[12] conversely, the dermis expresses 11β-HSD1 and the skin overall can convert DHEA into its oxygenated metabolites.[12]


7Interactions with Hormones

7.1. Cortisol

7-keto and the oxygenated DHEA metabolites interconvert using some of the enzymes used in cortisol metabolism (11β-HSD1,[12] which also reduces cortisone into cortisol[37][38]). It is thought that interconversion of the two hydroxylated metabolites of DHEA via this enzyme competitively inhibit cortisone, and prevent the production of cortisol from cortisone.[39] This competitive inhibition has been noted at the concentration of 5-10µM with the β isomer being 7-fold more potent than the α isomer and 7-keto also being effective with a Ki of 1.13+/-0.15µM[12] and has elsewhere noted concentration-dependent inhibition on this enzyme[40] and may interfere with corticosterone as well as cortisone.[20] Depending on the context of the situation, the oxygenated DHEA metabolite are both substrate and inhibitors of this enzyme.[41]

At least one study has suggested that this effect may only have a role in a state of poor health,[20]

This inhibition appears to be mutual, with higher concentrations of glucocorticoids inhibiting the interconversion of oxygenated DHEA metabolites,[42] and when assessing 7α-hydroxyDHEA and the β isomer, they do not appear to directly interfere with the cortisol receptor or its activation, similar to parent DHEA.[43]

Mechanistically, 7-keto may prevent the conversion of cortisone into cortisol by competitively interfering with the enzyme that mediates the conversion

Application of 25mg 7-keto via a cream for 8 days has failed to significantly modify circulating cortisol levels over 100 days of assessment in otherwise healthy male volunteers.[22]

Despite the above mechanisms, not enough evidence assessing the levels of circulating cortisol following 7-keto supplementation

7.2. Androgens

When looking at the androgen receptor, all three oxygenated metabolites of DHEA show little efficacy in activating the androgen receptor.[44]

Application of 7-keto topical cream prior to sleep (conferring 25mg 7-keto via 5g emulgel) in 21 otherwise healthy males for 8 days has noted reductions in circulating testosterone sporadically on days 2, 23, 37, and 72 (with no significant differences on days 5-16 nor 51).[22] Throughout this study, there were no significant increases in epitestosterone until day 23 where epitestosterone remained elevated until day 100 when the study ended (with peak values after 6 weeks, reaching 55% higher than baseline).[22]

One study has failed to find any influence on testosterone levels in otherwise healthy obese adults using 200mg 7-Keto for 8 weeks, but only measured 6 individuals.[27]

No direct androgenic effects associated with 7-keto, the influence on circulating androgens appears unreliable based on limited evidence

7.3. Estrogen

When tested in vitro, 7-keto appears to activate the beta subset of the estrogen receptor (ERβ) with an EC50 around 500μM which is partially blocked by exemestane (aromatase inhibitor or AI); there was no apparent activity on the classical subset (ERα) and parent DHEA and DHEAS were eqipotent.[45] As activity was hindered with an AI and there was efficacy in HepG2 cells but not Hep293 (expressing[46] and not expressing[47] aromatase, respectively) it is though that 7-oxo can be metabolized into an estrogen.[45]

Application of 25mg 7-keto via a topical cream for 8 days has failed to note any decreases in serum estradiol during treatment, although a decrease in estraiol was noted on days 72 and 100 (reaching 48% of baseline value) which coincided with decreases in serum SHBG.[22] 200mg of 7-keto for 8 weeks in otherwise obese persons in combination with exercise and a calorically restricted diet failed to significantly influenced estradiol levels in serum (this study only measured serum estradiol of 6 persons).[27]

May directly influence estrogen receptors, but only the beta subunit (not associated with classical effects of estrogen) and is quite weak at doing so; influences on circulating estrogen level is either a reduction or no effect but there is minimal evidence looking at this interaction

7.4. DHEA and related molecules

Topical application of 25mg 7-keto for 8 days has failed to significantly modify serum levels of the alpha metabolite (7α-hydroxyDHEA) while an acute increase in serum 7β-hydroxyDHEA was noted throughout treatment, with the latter normalizing on day 16 (first measurement day 9, the day after supplement cessation).[22] This study also noted no significant influence on serum DHEA nor DHEA sulfate.[22]

7.5. Sex Hormone Binding Globulin

Sex Hormone Binding Globulin (SHBG) is a globulin that binds to and inactives both estrogen and testosterone, and has a role in regulating steroid metabolism in vivo.[48]

Sex-Hormone Binding Globulin also decreased in the latter portion of the experiment (day 51, 72, and 100) despite no significant influence during treatment.[22]

7.6. Thyroid Hormones

7-Keto at 25mg daily has been shown to increase circulating Thyroid stimulating hormone (TSH) and both active thyroid hormones (T3 and T4) 5-9 days following topical application of 7-keto cream, with effects lasting for up to 2 weeks after cessation.[3] There was high inter-individual differences seen, with youth having greater circulating levels.

One study using 8 weeks of supplementation of 200mg 7-Keto noted that supplementation was associated with an increase in T3 by 17.88ng/dL while placebo increased T3 by 2.75ng/dL while both T4 and TSH were unaffected after 8 weeks.[27]

7-keto supplementation may have a small enhancement on thyroid hormones

7.7. Gonadotropins

Application of 25mg 7-keto via cream for 8 days in otherwise healthy males has been associated with a reduction in Luteinizing Hormone (LH) by 46% and Follicle Stimulating Hormone (FSH) by 25% when measured the day after the cream was starting to be appled, but were not reliably reduced in 100 days of followup (with a slight increase in FSH on day 100).[22]


8Safety and Toxicology

7-Keto does not appear to be associated with side-effects at up to doses of 200mg daily for 4 weeks in otherwise healthy young males.[5]

Scientific Support & Reference Citations

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