DMAA is a neurological stimulant which causes a quick spike of energy similar to Caffeine and other classical stimulants, but does so by different mechanisms in the brain.
It was first introduced as a nasal decongestant as 'Germanium Oil Extract' but more recently is used as a neurological stimulant and party pill.
Due to its structural similarity to amphetamines, it gives a false positive in drug tested competitions for amphetamines and thus should not be used by competing athletes.
It is not a highly studied compound in isolation.
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4-methylhexan-2-amine, DMAA, Dimethylamylamine, 1,3-DMAA, Geranamine, Methylhexaneamine, 1,3-Dimethylpentylamine, Forthane
DMAA is highly stimulatory.
DMAA may cause a false positive for amphetamines in urine testing.
The World Anti-Doping Agency has added methylhexanamine to the 2010 prohibited list, and while usage of 1,3-DMAA in the american military appears to be restricted the Australian government has classified DMAA as a Schedule 9 substance (2012) and prohibits its sales.Examine.com Medical Disclaimer
A typical starting dose of 1,3-DMAA is in the 10-20mg range and eventually reaching up to 40-60mg a day, there is no actual evidence to support this dosage range but it seems to be the standard dosages range for supplemental 1,3-DMAA on the market.
1,3-DMAA is known to be banned by various sports organizations due to its amphetamine-like nature, and should not be used by tested athletes.
Although there are many anecdotes of the efficacy of 1,3-DMAA, most (if not all) of the science is extrapolated from other compounds which act in a similar manner.
Although the compounds are very similar and this extrapolation should be relatively valid, some degree of caution should still be exerted until some studies on the 1,3-DMAA molecule itself are published.
The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what effect 1,3-Dimethylamylamine has in your body, and how strong these effects are.
|Grade||Level of Evidence|
|A||Robust research conducted with repeated double blind clinical trials|
|B||Multiple studies where at least two are double-blind and placebo controlled|
|C||Single double blind study or multiple cohort studies|
|D||Uncontrolled or observational studies only|
|Level of Evidence ||Effect||Change||Magnitude of Effect Size ||Scientific Consensus||Comments|
The increase in blood pressure with 1,3-DMAA was fairly notable and of concern, with 75mg paired with caffeine (common in preworkout supplements) increasing systolic by up to 20%.
No significant effect on heart rate noted with DMAA supplementation despite the increase in blood pressure.
DMAA is a straight chain, 7 carbon, aliphitic amine with a structural similarity to amphetamine, methamphetamine, and MDMA. It was first introduced as a nasal decongestant but more recently is used as a neurological stimulant and party pill.
DMAA also shares structural similarity to Propylhexedrine, a stimulant drug and nasodilator which may have fat-burning effects in vivo.
Due to its structural similarities, its mechanism of action may be as an adrenaline mimetic; inducing the same effects as adrenaline and the preceding compounds in vivo. However, direct studies on the pharmacokinetics of DMAA metabolism do not exist.
Although seemingly well tolerated in pre-workout supplemental form, DMAA has been linked to a cerebral haemorrhage in a case study with party pill usage.
No long-term toxicity studies are in existence, although acute LD50 of DMAA has been established at 39mg/kg bodyweight intravenous injection and 185mg/kg bodyweight intraperitoneal injection. Theoretically well below what can be achieved via oral ingestion.
DMAA, touted as being a component of geraniums, has been failed to be detected in geranium oil in one independent lab analysis.
DMAA causes a false positive for amphetamines in drug-tested sports competitions and should not be used by athletes being moderated by a drugs ethics association.
(Common misspellings for 1,3-Dimethylamylamine include dimethylamine, dimethylamylamin, dimethlamilamine, dimethlamylamine)
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