1,3-Dimethylamylamine
Looking to Buy Some 1,3-Dimethylamylamine?
Buy from Amazon.comSummary (The Good, The Bad, and all other Essential Benefits/Effects/Facts Information)
DMAA is a neurological stimulant which causes a quick spike of energy similar to Caffeine and other classical stimulants, but does so by different mechanisms in the brain.
It was first introduced as a nasal decongestant as 'Germanium Oil Extract' but more recently is used as a neurological stimulant and party pill.
Due to its structural similarity to amphetamines, it gives a false positive in drug tested competitions for amphetamines and thus should not be used by competing athletes.
It is not a highly studied compound in isolation.
Editors' Thoughts on 1,3-Dimethylamylamine
Although there are many anecdotes of the efficacy of 1,3-DMAA, most (if not all) of the science is extrapolated from other compounds which act in a similar manner.
Although the compounds are very similar and this extrapolation should be relatively valid, some degree of caution should still be exerted until some studies on the 1,3-DMAA molecule itself are published.
Also Known As
4-methylhexan-2-amine, DMAA, Dimethylamylamine, 1,3-DMAA, Gerananime, Methylhexaneanime, 1,3-Dimethylpentylamine, Forthane
Do Not Confuse With
DMAE, Memantine (Same acronym, different compound)
Is a Form of
How to Take (recommended dosage, active amounts, other details)
A typical starting dose of DMAA is in the 10-20mg range , eventually reaching up to 40-60mg a day.
(NOTE: These dosages are based on anecdotes of what works, and are not supported by the literature as there is a lack of it)
Looking to Buy Some 1,3-Dimethylamylamine?
Buy from Amazon.comThings to Note
DMAA is highly stimulatory.
Caution Notice (just some FYI - if needed)
DMAA may cause a false positive for amphetamines in urine testing.
In 2009, the World Anti-Doping Agency added methylhexanamine to the 2010 prohibited list.
It is currently being restricted from usage in the American military due to not falling under claims of it being from natural sources (a nutraceutical).[1]
Examine.com DisclaimerDetailed Summary
Table of Contents:Edit1. Structure and Function
DMAA is a straight chain, 7 carbon, aliphitic amine with a structural similarity to amphetamine, methamphetamine, and MDMA.[2] It was first introduced as a nasal decongestant[3] but more recently is used as a neurological stimulant and party pill.
DMAA also shares structural similarity to Propylhexedrine, a stimulant drug and nasodilator which may have fat-burning effects in vivo.
Due to its structural similarities, its mechanism of action may be as an adrenaline mimetic; inducing the same effects as adrenaline and the preceding compounds in vivo. However, direct studies on the pharmacokinetics of DMAA metabolism do not exist.
Edit2. Safety and Legality
2.1. Acute safety
Although seemingly well tolerated in pre-workout supplemental form, DMAA has been linked to a cerebral haemorrhage in a case study with party pill usage.[4]
No long-term toxicity studies are in existence, although acute LD50 of DMAA has been established at 39mg/kg bodyweight intravenous injection and 185mg/kg bodyweight intraperitoneal injection.[5] Theoretically well below what can be achieved via oral ingestion.
2.2. Legality
DMAA, touted as being a component of geraniums, has been failed to be detected in geranium oil in one independent lab analysis.[6]
2.3. Drug Testing in Competitions
DMAA causes a false positive for amphetamines in drug-tested sports competitions and should not be used by athletes being moderated by a drugs ethics association.[2]
Edit3. Effect on Blood Pressure
DMAA alone and in combination with Caffeine has been shown in a double blind trial to significantly increase blood pressure, but had not effect on heart rate.[7]
Scientific Support & Reference Citations
References
- Military probe adding to skepticism of DMAA
- Vorce SP, et al. Dimethylamylamine: a drug causing positive immunoassay results for amphetamines. J Anal Toxicol. (2011)
- [No authors listed. NEW and nonofficial remedies: methylhexamine; forthane. J Am Med Assoc. (1950)
- Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J. (2010)
- The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (Book)
- Lisi A, et al. Studies of methylhexaneamine in supplements and geranium oil. Drug Test Anal. (2011)
- Bloomer RJ, et al. Effects of 1,3-dimethylamylamine and caffeine alone or in combination on heart rate and blood pressure in healthy men and women. Phys Sportsmed. (2011)
Last Updated: May 2, 2012 13:22:33
(Common misspellings for 1,3-Dimethylamylamine include dimethylamine, dimethylamylamin, dimethlamilamine, dimethlamylamine)(Common phrases used by users for this page include dmaa drug, dmaa amphetamine, dimethylamylamine amphetamine, Dimethylamylamine Dosage, Dimethylamylamine 1,3, 1,3-dimethylamylamine amphetamine positive)
(Users who contributed to this page include Silverhydra, rrobe53, SoloX, Pwoolf, divor, scrinmaster, Robotra)
