PES Erase and Science

There is a supplement making the rounds as of late called 'PES Erase', touted to be an aromatase inhibitor and muscle builder. The official name of the molecule in PES Erase is:

  • Androsta-3,5-diene-7,17-dione

Which, I have been told, gives off very 'steroid-y vibes' to a lot of people. However, PES declares that their supplement is DSHEA approved and a legitimate nutraceutical; this insinuates that the above compound is naturally occurring and not a synthetic compound.

Now for Examine's thoughts; or at least, this editor's thoughts.

  • Please note that I have used PES Erase in the past with good success, so my (Silverhydra) thoughts may be biased.

Please refer to the Serum DHEA page, specifically summary 14 called 'Notable Derivatives'. It appears the above supplement is a DHEA derivative. In the subsection 14 it notes two compounds, 7-Keto (a brand name derivative of DHEA) and this compound.

It appears that DHEA can be metabolized into 7-Keto (interchangeably known as 7-Oxo), which has been known for some time, but that 7-Oxo can be further metabolized into the above Androsta-3,5-diene-7,17-dione. This latter compound has been isolated in the urine, and thus appears to be naturally occurring in the human body.

So regardless of whether or not it is a 'steroid' or a 'pro-hormone'; it does not appear to be a synthetic compound. Additionally, it is unlikely that it itself will convert into androgens despite that, via inhibiting aromatase (which in vitro studies suggest is quite potently so) it can otherwise increase testosterone. This is all theory at this moment, as no human or animal interventions have been conducted with Androsta-3,5-diene-7,17-dione.


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