Yes.
To clarify, when it comes to weight loss, the only thing that matters are calories in vs calories out. Macro composition does not matter.
With that in mind, relative to a high-carb diet, a low-carb diet has been shown to improve fasting plasma glucose and insulin levels, cholesterol levels, blood triglycerides, preserve muscle mass during weight loss, and other health markers.[1][2][3][4][5][6][7][8][9]